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Neo-adjuvant Pembrolizumab in dMMR/ POLE-EDM uterine cancer patients: a feasibility study

We aim to establish proof-of-concept for use of pembrolizumab as novel neo-adjuvant therapy in dMMR and POLE-EDM UC. When ICB proves to be feasible as defined in the primary endpoint (see 2.1), we will follow-up with larger studies to determine…

Phase III Randomized clinical trial for stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy: OVHIPEC-2

This study has been transitioned to CTIS with ID 2023-509049-11-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the effect of HIPEC on overall survival when added to primary cytoreductive surgery…

Adjuvant vaccination against HPV in surgical treatment of CIN lesions, a Randomised Controlled Trial.

Evaluate the efficacy of nonavalent HPV vaccination in women with a CIN lesion who will undergo or have undergone a LEEP in preventing recurrent CIN II-III after 24 months.

Changes in body composition during and after external beam radiotherapy for gynaecologic cancer

The primary objective of this study is to assess if clinically relevant changes occur in fat free mass (FFM) between baseline and follow up six months after the end of treatment. Our cut-off value of a clinically relevant difference in body…

Groningen International Study on Sentinel nodes in Vulvar cancer - III, a prospective phase II treatment trial

This study has been transitioned to CTIS with ID 2023-508722-99-00 check the CTIS register for the current data. Primary objective:- Investigate the safety of replacing inguinofemoral lymphadenectomy by chemoradiation in early stage vulvar cancer…

Mechanisms explaining psychological Distress In CErvical cancer patients and partners (DICE): a population-based prospective study

1. What is the level of psychological distress among cervical cancer patients over time?2. What is the role of characteristics of the individual, characteristics of the environment, biological function, overall quality of life, functional status and…

Treatment of metastatic vulvar carcinoma in a neoadjuvant setting with Carboplatin and Paclitaxel chemotherapy

Main objective: response rate and tumour size reduction by chemotherapy

An exploratory study: Dendritic cells for immunotherapy of metastatic endometrial cancer patients

The primary objective of this exploratory study is to show immunologic efficacy of tumor-peptide and tumor lysate-loaded natural DC in mEC patients undergoing chemotherapy. The immune-monitoring will include: a) functional response and dextramer…

An open-label, single arm, prospective, multi-center, tandem two stage designed, phase II study to evaluate the efficacy of Fulvestrant in women with recurrent/metastatic estrogen receptor positive gynecological malignancies

Evaluate the efficacy of the ER-antagonist Fulvestrant in women with estrogen receptor positive (ER+) low grade gynecological cancers

Treatment of locally advanced VULvar CArcinoma in a Neoadjuvant setting with Carboplatin and Paclitaxel chemotherapy

Main objective: response rate and tumour size reduction by neoadjuvant chemotherapy.

Determining prognostic immune markers in patients with ovarian cancer * a prospective explorative cohort study.

Primary objectiveInvestigate if mMDSC/DC ratio in peripheral blood mononuclear cells (PBMCs) in patients with recurrent EOC before the start of treatment is associated with OS.See page 11 of the research protocol for secundary objectives.