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Assessment of tumor hypoxia in laryngeal cancer with 18F-fluoroazomycin arabinoside (18F-FAZA)-PET/CT scanning, oxygen-enhanced MRI (OE-MRI) and immunohistochemistry

To determine the accuracy of 18F-FAZA-PET/CT and OE-MRI scan in detecting hypoxic regions within the tumor using histological markers.

Diagnostics using perfusion CT imaging to determine the extent of bone marrow involvement of the mandible by squamous cell carcinoma - a pilot study

To demonstrate the extent of bone marrow invasion of the mandible by SCC. Can perfusion CT imaging demonstrate the extent of bone marrow invasion of the mandible by SCC? If so, it can prevent unnecessary resection of the mandible.

Perfusion PET Sarcoma: Feasibility of tumor perfusion quantification with Gallium-68-citrate PET/CT in sarcoma and radiotherapy

The study aims (1) to determine the feasibility of Perfusion-PET with Gallium-68-citrate, prior to and during radiotherapy, and (2) to better understand the process of vascular response of tumor to radiotherapy, including differences between MLS and…

FaR-RMS - An overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma

This study has been transitioned to CTIS with ID 2024-510579-40-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Phase 1 Dose Finding Studies:-To determine the recommended phase II dose (RP2D) of new systemic therapy regimens. *…

*Systemic Metal Ion Concentrations in Patients with a PEEK HD coupling mechanism in the Modular Mega-prostheses of the Knee; a prospective cohort pilot study*

Objective: We aim to 1) monitor and investigate the change in serum metal ion (Cobalt and Chrome) levels postoperatively (at 3-6, 12 and 24 months) in patients receiving a primary PEEK HD coupling mechanism, monitor and investigate the change in…

Body image, health-related quality of life, and function after soft tissue sarcoma resection

Primary objectives : 1- To assess body image, health-related quality of life, self-reported activity limitations, and pain after STS resections as defined in the ICF domains. 2- To assess the functioning of the patients after STS resections as…

Towards a minimally invasive approach of atypical lipomatous tumors: the MINIMALIST study

The aim is to develop a minimally invasive approach of both diagnosing and treating ALTs, saving these patients a biopsy, surgery-related complications and morbidities amongst others. As a first step towards a minimally invasive diagnosis, a…

Surveillance AFter Extremity Tumor surgerY International Randomized Controlled Trial

Does the frequency and mode of surveillance affect patient survival following extremity STS surgery?

Real-time margin assessment in head and neck cancer - enhancing specificity by combining fresh frozen sectioning with targeted fluorescence imaging
The LIGHTNING study

The main aim is to test whether cetuximab-IRDye800CW is a reliable marker for residual tumor remnants in resection margins after surgical removal of head and neck cancer. To increase the specificity of cetuximab-800CW, a specific frozen section can…

The Feasibility of Multispectral Optoacoustic Tomography in different diseases: a phase 1 explorative imaging study

- The technical feasibility of multispectral optoacoustic tomography for the localization and assessment of disease-specific tissue in a particular anatomical area- Detection of endogenous biomarkers for the characterization in a variety of diseases

FLuoresence image guided surgery with A VEGF-targeted tracer in soft-tissue Sarcomas in Humans

Part 11. Determine if accumulation of the fluorescent tracer bevacizumab-800CW can be detected for identification of soft tissue sarcoma during surgery.2. Identify two doses of bevacizumab-800CW that provide the best visualization of tumour tissue…