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The value of nerve ultrasound in patients with neurofibromatosis type 1

This will be an explorative study to examine the value of high-resolution ultrasound (HRUS) of the peripheral nerves in NF1 patients. The primary objective of this study is to determine HRUS abnormalities in a large group of NF1 patients, and to…

A prospective study on the role of the cerebellar (para)flocculus in tinnitus: the relation with electrophysiological parameters and inflammatory mediators

Module 1Primary Objective: To objectify the relation between tinnitus and flocculus activity, quantified by direct response measurements on the flocculus. Tinnitus is quantified by the Tinnitus Functional Index score (TFI), tinnitus pitch and…

The TRAIN study: Trametinib in neurofibromatosis type 1 related symptomatic plexiform neurofibromas

Primary objective: Response to trametinib treatment defined as a tumor volume decreases from baseline of >=20%, monitored by using volumetric MRI analysis. Secondary objectives are: patient reported outcomes of pain and disability and quality…