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Fluorescence guided surgery for intra-operative detection of meningioma using Bevacizumab-IRDye800CW

In the present study, we aim to perform a feasibility study with Bevacizumab-IRDye800CW in patients with meningioma who are scheduled for elective surgical resection. The ability of fluorescence imaging to identify residual meningioma tissue that is…

A Phase I/II, Single-Arm, Open-label Study to Evaluate the Pharmacokinetics, Safety/Tolerability and Efficacy of the Selumetinib Granule Formulation in Children Aged >= 1 to < 7 Years with Neurofibromatosis Type 1 (NF1) Related Symptomatic, Inoperable Plexiform Neurofibromas (PN) (SPRINKLE)

Primary objectives:- To determine the PK of selumetinib after administration of the selumetinib granule formulation. - To assess the safety and tolerability of the selumetinib granule formulation.

Study on two new methods for testing visual field in children with brain disease

To compare different methods for visual field testing in young and/or neurologically impaired children, to determine which test is most useful in detecting visual field defects.

Prospective Evaluation of Vestibular Schwannoma Irradiation

Primary Objectives: • To evaluate the subjective and objective cognitive complaints and cognitive function in patients receiving radiotherapy for their vestibular schwannoma. Secondary objectives:• To explore the use of (MRI) imaging biomarkers for…

PREselection of patients at risk for COgnitive DEcline after Radiotherapy using advanced MRI
(PRECODE-MRI)

To investigate the dose-response relation between cognitive decline and radiotherapy dose for patients with a benign meningioma WHO I.