185 results
Exploring and documenting the end-of-life phase in HGG patients: duration; residence (at home, nursing home, hospice, hospital); transfers between care settings, medical problems; palliative treatment/care; end-of-life decisions and cause of death…
The goal of this study is to improve risk stratification and treatment allocation for medium and high risk neuroblastoma patients by real time quantitative (RQ)- PCR-minimal residual disease (MRD) testing.We have recently developed a panel of RQ-PCR…
Exploring (1) cognitive functioning in WHO grade I meningioma patients, and (2) the relation between cognitive functioning and functional connectivity in this patient group.
The objective of the study is to confirm that PCNSL is positive on 89Zr-rituximab PET imaging.
Primary Objectives: To identify the rate of successful AED withdrawal in LGG and anaplastic glioma patients with epilepsy and long-term seizure freedom after anti-tumour therapy. Secondary Objectives: - Exploring the physician*s and patient*s…
The evaluation of the safety and pharmacokinetics of ABT-414 in combination with radiation plus temozolomide or temozolomide alone for subjects with Glioblastoma Multiforme.
The purposes of this study are to uncover 1. Which surgical methods are least likely to cause the CMS and if there is a difference in risk between primary surgery and re-operation 2. Which patients may be genetically predisposed to developing the…
This study aims at determining to what extent brain tumor patients have limitations in social cognition, if these limitations are dependent on patient, tumor, or treatment characteristics, and how these limitations affect functioning of informal…
In the future, the determination of CTCs and ctDNA in the CSF could be a new quantitative method for the anti-tumor response assessment of systemic or intrathecal therapy (as opposed to CSF cytology, which is subjective and not a quantitative method…
Primary objective:• To determine the efficacy of selinexor in adults with recurrent GBM asdetermined by the 6-months progression-free survival (6mPFS) rateSecondary objectives:• To determine the efficacy of selinexor in adults with recurrent GBM…
The primary goal is to compare functional (language) areas in the brain found by preoperative fMRI, to those found during intraoperative ESM (electrical stimulation mapping) and fUS (functional ultrasound) during awake craniotomies, to see whether…
To test whether extremely hypofractionated radiotherapy (6 x 6 Gy) is non-inferior to standard radiotherapy (30 x 2 Gy) in terms of overall survival in patients with newly diagnosed GBM. Secondary objectives are to establish and compare health…
The primary objective of this study is to compare overall survival (OS) in patients receiving Marizomib in combination with standard treatment (TMZ with concomitant RT, followed by TMZ maintenance therapy: TMZ/RT*TMZ) with patients receiving…
Objectives: • To report treatment outcomes and radiation-induced toxicity from a prospective, multicentre observational cohort of IDHmG patients treated with radiotherapy and chemotherapy,• To intergrate radiotherapeutic dose distributions, imaging…
To determine if re-irradiation in 4 fractions is non-inferior to 10 fractions in the primary endpoint of survival after re-irradiation. Secondary objectives are to establish and compare health related quality of life (HRQoL), recurrence patterns,…
Primary objective* To evaluate the efficacy in terms of overall survival (OS) of erlotinib, everolimus and dasatinib in combination with radiation therapy, in patients with a DIPG both: - compared to the other experimental treatments by comparisons…
Implementation of liquid biopsy by NGS in cell-free circulating tumor DNA in CSF and / or blood, in patients clinically suspected of leptomeningeal metastases and / or brain metastasesDemonstrate that the detection of additional tumor mutations in…
The primary objective is to identify and describe radiological tumor characteristics of glioma on 7 T MRI (possible relevant sequences: 3DT1, 3DT2, TOF, SWI (Duyn), FLAIR, spectroscopy and CEST) and 1.5/3 T MRI (relevant sequences: T1WI with and…
To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours.
In this project, we focus on the cortical network (connectome) involved in visuomotor control. The projects aims to:- Map out higher order visual and motor functions in primary brain tumour patients. - Explain variability in performance on the basis…