185 results
Firstly, to assess the ability of fUS to discriminate between functional and non-functional brain areas using task-specific brain-activity during an awake neurosurgical procedure. Secondly, to assess the ability of fUS to discriminate between…
The current study aims to primarily investigate associations between multimodal networks in glioma patients. Secondary objectives include investigation of the correlations between multimodal neural networks and cognition and epilepsy and linking…
Our central hypothesis is that the RNA content of TEPs allows for the identification of glioblastoma progression, including the differentiation from pseudo-progression and radionecrosis. For this we plan to use two parallel approaches, i.e. the TEP-…
Primary objective is to study the association with preoperative 2-HG concentration, and progression free time in patients with a low grade glioma that are treated with vorasidenib.
We aim to determine the added value of a direct FET-PET for clinical practice. The hypothesis is that the addition of FET-PET will lead to correct diagnosis more rapidly than regular MRI alone, and thus to a better quality of life for patients…
The development of an objective, standardized and validated tool for the assessment of clinical outcome of brain tumor patients
This study has been transitioned to CTIS with ID 2024-510767-30-00 check the CTIS register for the current data. 1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal brain metastases - Concordance between fluorescent…
Primary Objective Our primary aim is to compare cognitive decline at 3 months, defined as a significant decline (5 point decrease from baseline based on the reliable change index with correction for practice effects) in HVLT-R Total Recall score (…
To investigate the efficacy of bCBT compared to usual care in severely fatigued patients with primary brain tumors.
The current standard treatment for glioblastoma is a combination of surgery, radiation therapy (abbreviated RT), and temozolomide (abbreviated TMZ). The purpose of this study is to test the safety (any good or bad effects) of CC-90010 when combined…
Long-term survival in glioblastoma will be addressed in a highly collaborative and comprehensive working program focusing on patient characteristics and (host)- related factors, identification of molecular tumor characteristics, therapy-related…
The primary objective is to explore changes in cerebrovascular reactivity and tissue oxygenation prior to and after high-grade glioma resection, and before and after (chemo)radiation using 7T MRI by respiratory challenges which induce hypercapnic…
Primary Objective:Determine the optimal threshold on APTw-CEST images in a multi-center (4 academic insti-tutes) multi-vendor (Philips, Siemens and GE) clinical trial, to distinguish tumor progression from treatment-related effects. Secondary…
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…
In this project we aim to develop a safe and effective technique for ADC/FET-guided resection of IDH-wildtype glioblastoma and grade IV IDH-mutant astrocytoma. The safety concerns neurological deficits and time to start of adjuvant therapy, while…
Identifying the (immune) cell composition, co-localization, functions, and alterations as well as blood and lymph vessels reorganisation in the human*s dura, arachnoid and pia mater, and skull bone marrow in high-grade glioma patients as compared to…
This study has been transitioned to CTIS with ID 2024-513392-40-01 check the CTIS register for the current data. The design will be a prospective, single center phase I feasibility and dose finding study in patients with high-grade glioma, to…
Conducting research into the role of CSF and blood parameters of patients with CNS lymphoma, focused on improving the diagnostics, identification of biomarkers ('liquid biopsy'), and evaluation of therapy effect.
This study has been transitioned to CTIS with ID 2024-510578-25-00 check the CTIS register for the current data. Primary objectives:- To evaluate whether the outcome in children, young people and adults with HR-MB is improved over standard therapy i…
We will investigate (1) whether broadband power can be measured repeatedly and accurately within this patient population with limited variation in case of stable disease, (2) whether meaningful changes in broadband power in the case of real…