185 results
Determine whether early postoperative treatment results in a longer survival without further treatments and in the end a longer overall survival, and whether earlier treatment results in the earlier occurence of delayed adverse effects of treatment
Primary Objective: The present study aims to generate detailed molecular characterization of paired tumor samples (i.e. obtained at first operation and at the time of tumor recurrence) of patients with glioma, with specific interest for at least 100…
To develop a non-invasive MR method to measure the local changes in glucose metabolism of human brain tumour, in order to answer to the question:Is the tumour glucose metabolism anaerobic?
In preparation of a randomized controlled trial, we aim to assess pilot data on technical feasibility and safety of LITT and to assess practical feasibility of a randomized study in patients with primary irresectable glioblastoma, as compared with…
To characterize glioma and epileptogenic tissue with 7T metabolic MRI, and validate their metabolic imaging characteristics with histopathological measures.
The primary objective is to investigate the efficacy of HIIT on self-reported physical fitness in primary brain tumor patients during stable disease. The secondary objective is to investigate the efficacy of HIIT on the maximal oxygen uptake (VO2max…
The purposes of this study are to uncover- Which clinical and neuroradiological measures can be used to predict the (neuropsychological) outcome and progression of symptoms in children with CMS?We hope that the results will contribute to an overall…
To evaluate and compare the survival outcome of patients with first recurrence of glioblastoma undergoing surgical debulking/resection followed by either implantation of the SC9 device and repeat BBB opening in association with carboplatin…
The primary objective is to improve the accuracy to predict glioma genotype of our previously developed algorithm *PrognosAIs* by adding advanced MRI acquired before surgery. The secondary objective is to learn the relationship between MRI signal…
Primary objective• To determine the MTD/RPTD for CQ in combination with concurrent radiotherapy with daily TMZ in patients with a newly diagnosed GBM.Secondary objectives• To characterize the safety and tolerability of CQ in combination with…
To determine the diagnostic accuracy of VAI for the differentiation of treatment effects from tumour progression.
Primary goal is to investigate if the 2-HG peak on in vivo MR spectroscopy correlates with the ex vivo IDH mutation and 2-HG concentration in patients with a low grade gliomas.
This study aims to establish the diagnostic accuracy of functional MRI techniques and MET-PET individually and combined in treatment evaluation of glioblastoma.
Primary objective To evaluate the Overall Response Rate (CR/PRrate) in patients treated with pembrolizumab for recurrent or progressive PCNSL after MTX-based first-line therapy To evaluate the safety of pembrolizumab in subjects diagnosed with…
(1) to assess the diagnostic accuracy of advanced neuroimaging compared with standard MRI for the detection of diffuse glioma infiltration within the brain in newly diagnosed patients, (2) to histopathologically and molecularly characterize the…
Main aim:Identify the optimal urinary catecholamine metabolites panel for neuroblastoma diagnostics.Sub-aims:1. Investigate whether catecholamine metabolites can also be linked to prognosis and thus assist in risk assessment.2. Investigate whether…
Primary objective: To establish anatomical variations (position, shape, size) and functional MRI parameters (permeability, perfusion and diffusion) in the target volume before and during fractional radiotherapy treatment for brain lesions.Secondary…
The main objective of this pilot study is to determine PKI concentration in tumor tissue after approximately two weeks of treatment.
To determine the correlation between neurocognitive function and the incidence of DTI abnormalities on MRI in irradiated glioma patients.
Primary:To evaluate the feasibility and safety of intra-tumour and peri-tumour therapy with GMP hBMP4 in increasing doses in patients with progressive and/or multiple recurrent GBM, identify DLT, and to determine whether there is a maximum tolerated…