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Development of a questionnaire to measure instrumental activities of daily living (I-ADL) in patients with brain tumors

Primary Objective: The overall aim of this study is to develop a reliable and valid IADL questionnaire for use in brain tumor patients. Parallel versions of this questionnaire will be developed; a patient-based version and a proxy-based version.…

Health-related quality of life, disease burden and cognition in meningioma patients and their informal caregivers

Primary Objectives The main objective of this project is to evaluate the long-term disease burden in meningioma patients. More specifically, we will evaluate: 1) the level of cognitive functioning and HRQoL in meningioma patients at least 5 years…

Glioma stem cell organoids: preclinical model of glioblastoma heterogeneity to explore resistance mechanisms to conventional treatment schedules.

to establish primary patient derived organoid cultures from GM to study mechanisms that contribute to aggressive tumor growth and treatment resistance in primary and recurrent GM.

Social cognition in children treated for a brain tumour: A comparative prospective international multi-centre study

Primary Objective: 1) To study impairment and developmental delay in social cognition (and related cognitive functions) caused by brain damage in patients treated for a brain tumour in childhood as compared to a reference group of chronically ill…

Non-invasive assessment of local glucose levels and the uptake and metabolism of glucose in tumour in the human brain using Magnetic Resonance at 3T.

To develop a non-invasive MR method to measure the local changes in glucose metabolism of human brain tumour, in order to answer to the question:Is the tumour glucose metabolism anaerobic?

Pilot study investigating the relationship between neurocognitive function, radiotherapy and cerebral white matter microstructure in low grade glioma patients by using MRI diffusion tensor imaging

To determine the correlation between neurocognitive function and the incidence of DTI abnormalities on MRI in irradiated glioma patients.

Realtime language mapping during awake brain surgery

The primary goal is to compare functional (language) areas in the brain found by preoperative fMRI, to those found during intraoperative ESM (electrical stimulation mapping) and fUS (functional ultrasound) during awake craniotomies, to see whether…

Phase 3b Study for Management of Ocular Side Effects in Subjects with EGFR-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414)

This exploratory study is designed to evaluate several depatuxizumab mafodotin-related OSE management strategies.The main objective of this trial is to estimate the percentage of subjects in each prophylactic treatment arm who require a change in…

The long-term impact of immunotherapy and targeted therapy on outcomes in patients with brain metastases

To determine outcomes in long-term surviving brain metastases patients (>=2 years after diagnosis of brain metastases) treated with immunotherapy or targeted therapy.

Cognitive functioning and health-related quality of life in long-term anaplastic oligondendroglioma and oligoastrocytoma survivors from the EORTC 26951 study: second follow-up

Primary objective: To assess NCF, HRQoL, mood, fatigue, cognitive complaints and health care utilization in long-term surviving patients with anaplastic oligondendroglioma and oligoastrocytoma.Secondary objective:To assess cerebral abnormalities in…

The EndoWatch: a smart wearable that serves as *external hypothalamus*

The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…