26 results
Primary Objective: The overall aim of this study is to develop a reliable and valid IADL questionnaire for use in brain tumor patients. Parallel versions of this questionnaire will be developed; a patient-based version and a proxy-based version.…
The primary study objectives are: (1) to determine the impact of glioma and its treatment on the neurocognitive functioning, health-related quality of life, and mental functioning of LGG patients; and (2) to determine the impact of the disease and…
Primary Objectives The main objective of this project is to evaluate the long-term disease burden in meningioma patients. More specifically, we will evaluate: 1) the level of cognitive functioning and HRQoL in meningioma patients at least 5 years…
to establish primary patient derived organoid cultures from GM to study mechanisms that contribute to aggressive tumor growth and treatment resistance in primary and recurrent GM.
The overall objective of the MOBI-KIDS study is to assess the potential carcinogenic effects of childhood and adolescent exposure to RF and ELF from mobile telephones on the central nervous system (CNS). In order to achieve the overall objective,…
The current study aims to investigate whether neural network characteristics of the brain can predict the frequency and severity of epileptic seizures in brain tumor patients. Our secondary objective is to determine the correlation between seizures…
Our hypothesis is that a left hemisphere tumor causes language dysfunction by mass effect on or infiltration of white matter tracts connecting Wernicke's area with Broca's area and between Broca's area and the SMA. The neurosurgical…
Primary: The major aim is to identify peptides naturally presented on glioblastoma tumors but not on healthy tissue to set up a glioblastoma specific database for potential application for immunotherapeutic aproaches.secondary: a protocol for tumor…
Exploring (1) cognitive functioning in WHO grade I meningioma patients, and (2) the relation between cognitive functioning and functional connectivity in this patient group.
The purposes of this study are to uncover 1. Which surgical methods are least likely to cause the CMS and if there is a difference in risk between primary surgery and re-operation 2. Which patients may be genetically predisposed to developing the…
This study aims at determining to what extent brain tumor patients have limitations in social cognition, if these limitations are dependent on patient, tumor, or treatment characteristics, and how these limitations affect functioning of informal…
The primary goal is to compare functional (language) areas in the brain found by preoperative fMRI, to those found during intraoperative ESM (electrical stimulation mapping) and fUS (functional ultrasound) during awake craniotomies, to see whether…
In this project, we focus on the cortical network (connectome) involved in visuomotor control. The projects aims to:- Map out higher order visual and motor functions in primary brain tumour patients. - Explain variability in performance on the basis…
Primary objective: To assess NCF, HRQoL, mood, fatigue, cognitive complaints and health care utilization in long-term surviving patients with anaplastic oligondendroglioma and oligoastrocytoma.Secondary objective:To assess cerebral abnormalities in…
The current study aims to primarily investigate associations between multimodal networks in glioma patients. Secondary objectives include investigation of the correlations between multimodal neural networks and cognition and epilepsy and linking…
Long-term survival in glioblastoma will be addressed in a highly collaborative and comprehensive working program focusing on patient characteristics and (host)- related factors, identification of molecular tumor characteristics, therapy-related…
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…
Identifying the (immune) cell composition, co-localization, functions, and alterations as well as blood and lymph vessels reorganisation in the human*s dura, arachnoid and pia mater, and skull bone marrow in high-grade glioma patients as compared to…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
To determine outcomes in long-term surviving brain metastases patients (>=2 years after diagnosis of brain metastases) treated with immunotherapy or targeted therapy.