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A phase III trial of marizomib in combination with standard temozolomide-based radiochemotherapy versus standard temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma- MIRAGE

The primary objective of this study is to compare overall survival (OS) in patients receiving Marizomib in combination with standard treatment (TMZ with concomitant RT, followed by TMZ maintenance therapy: TMZ/RT*TMZ) with patients receiving…

The Cohort for patient-reported Outcomes, Imaging and trial inclusion in Metastatic BRAin disease

1) To collect information on patient characteristics, short and long-term clinical and patient reported outcomes and those of his/her caregiver. 2) To evaluate feasibility, performance and added value of new magnetic resonance imaging (MRI)…

A Phase 1/2 Study of the Oral TRK Inhibitor larotrectinib in Pediatric patients with Advanced Solid or Primary Central Nervous System Tumors

This study has been transitioned to CTIS with ID 2022-502668-20-00 check the CTIS register for the current data. PHASE 1 OBJECTIVES:Primary:To determine the safety of oral larotrectinib , including dose-limiting toxicity (DLT), in pediatric patients…

Intraoperative functional Ultrasound (fUS)-imaging during awake and anesthetized neurosurgical procedures

Firstly, to assess the ability of fUS to discriminate between functional and non-functional brain areas using task-specific brain-activity during an awake neurosurgical procedure. Secondly, to assess the ability of fUS to discriminate between…

A Phase 1/2 Study of Oral LOXO-292 in Patients with Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors with RET Activation (LIBRETTO-001)

Primary objective:To determine the MTD/recommended dose for further study of oral LOXO-292 in patients with advanced solid tumors, including RET-fusion NSCLC, MTC, and other tumors with increased RET activity.Secondary objectives:* To determine the…

Phase 3b Study for Management of Ocular Side Effects in Subjects with EGFR-Amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414)

This exploratory study is designed to evaluate several depatuxizumab mafodotin-related OSE management strategies.The main objective of this trial is to estimate the percentage of subjects in each prophylactic treatment arm who require a change in…

18F-PSMA PET/CT for visualization of glioblastoma multiforme

Primary objective: * Determine the feasibility of using 18F-PSMA PET/CT for visualization of GBM.Secondary objectives:* Correlate PSMA RNA and protein expression with 18F-PSMA PET/CT uptake.

Study of TG02 in Elderly Newly Diagnosed or Adult Relapsed Patients with Anaplastic Astrocytoma or Glioblastoma: A Phase Ib Study (STEAM)

- to determine the recommended phase 2 dose of TG02 in combination with radiotherapy in older patients (>65 years of age) with IDHwt glioblastoma and anaplastic astrocytoma without MGMT promoter methylation- to determine the recommended phase…

Phase II open-label global study to evaluate the effect of dabrafenib in combination with trametinib in childeren and adolescent patients with BRAF V600 mutation positive low grade glioma (LGG) or relapsed or refractory High Grade Glioma (HGG)

This study aims to demonstrate the effectiveness of dabrafenib with trametinib in pediatric patients with BRAF V600 mutant relapsed refractory HGG.This study aims to demonstrate the effectiveness of dabrafenib with trametinib compared to…

Early prediction of Glioma Recurrence to Radiotherapy by 31P MRS and 1H CEST MRI

To non-invasively measure metabolic alterations in GBM with 31P MRS at 7T and CEST MRI at 3T and 7T before and after radiotherapy (after the first session and after the whole treatment), and compare these results with Cx30 levels obtained from pre-…

11C-erlotinib brain uptake in Diffuse Intrinsic Pontine Glioma imaged by PET

Primary objective:Non-invasively determining the 11C-erlotinib brain uptake in DIPG patients by PET imaging.Secondary objective:Determining the EGFR expression in DIPG

Pilot study for the treatment response evaluation in glioblastoma with vessel architectural imaging (VAI)

To determine the diagnostic accuracy of VAI for the differentiation of treatment effects from tumour progression.

Pilot to validate in vivo 2-HG MR spectroscopy in low grade gliomas

Primary goal is to investigate if the 2-HG peak on in vivo MR spectroscopy correlates with the ex vivo IDH mutation and 2-HG concentration in patients with a low grade gliomas.

Prospective Longitudinal Study Using Functional MRI and Met-PET Imaging for Treatment Evaluation in Glioblastoma Patients

This study aims to establish the diagnostic accuracy of functional MRI techniques and MET-PET individually and combined in treatment evaluation of glioblastoma.

Pilot study investigating the relationship between neurocognitive function, radiotherapy and cerebral white matter microstructure in low grade glioma patients by using MRI diffusion tensor imaging

To determine the correlation between neurocognitive function and the incidence of DTI abnormalities on MRI in irradiated glioma patients.

Dose and Volume Escalation of Preoperative Brain Irradiation in GBM Patients
- the POBIG trial

* To explore the single fraction dose and volume that can be safely given in a preoperative setting additional to the standard treatment of postoperative surgery and (chemo)radiation. * To assess the tumor control and (re)growth between surgery and…