17 results
Objectives: • To report treatment outcomes and radiation-induced toxicity from a prospective, multicentre observational cohort of IDHmG patients treated with radiotherapy and chemotherapy,• To intergrate radiotherapeutic dose distributions, imaging…
The primary objective is to identify and describe radiological tumor characteristics of glioma on 7 T MRI (possible relevant sequences: 3DT1, 3DT2, TOF, SWI (Duyn), FLAIR, spectroscopy and CEST) and 1.5/3 T MRI (relevant sequences: T1WI with and…
In this project, we focus on the cortical network (connectome) involved in visuomotor control. The projects aims to:- Map out higher order visual and motor functions in primary brain tumour patients. - Explain variability in performance on the basis…
The main goal is to identify risk factors for radiation induced cognitive changes. Therefore, cerebral hemodynamic status of the patient, measured as cerebrovascular reactivity (CVR) with magnetic resonance imaging (MRI), at the start of radiation…
In this study we will investigate whether there is a difference in PSMA expression between BM and RN by:1. Evaluating PSMA expression using Ga68-PSMA PET/CT in BM of NSCLC, melanoma and breastcancer patients eligible for SRT or surgery.2. Evaluating…
This study has been transitioned to CTIS with ID 2024-512222-28-00 check the CTIS register for the current data. Overall program:The overall aim of this project is to improve the outcome of patients diagnosed with ependymoma by improving the staging…
This study has been transitioned to CTIS with ID 2024-513724-42-00 check the CTIS register for the current data. PNET 5 MB-LR: Primary objective:-to confirm that the 3-year Event-Free Survival (EFS) rate in children and adolescents with standard-…
Primary objective: To assess NCF, HRQoL, mood, fatigue, cognitive complaints and health care utilization in long-term surviving patients with anaplastic oligondendroglioma and oligoastrocytoma.Secondary objective:To assess cerebral abnormalities in…
The primary objective is to explore changes in cerebrovascular reactivity and tissue oxygenation prior to and after high-grade glioma resection, and before and after (chemo)radiation using 7T MRI by respiratory challenges which induce hypercapnic…
The study will take place in 5 neurosurgical centers in the Netherlands (Erasmus MC, UMC Utrecht, Elizabeth Ziekenhuis Tilburg, MC Haaglanden The Hague, UMCG Groningen) and one center in Belgium (UZ Gent). All centers have ample experience with the…
Overall ObjectiveThe purpose of the study is to compare the effect of craniotomy and tumor resection followed by adjuvant second-line therapy to no surgery followed by second-line therapy on overall survival, neurological status, and quality of life…
Primary objective:To study whether changes in OCT parameters lead to earlier detection of visual decline compared to standard ophthalmological testing (visual field, visual acuity) in children with a brain tumor. Secondary objective: To study the…
Primary objectiveTo assess the safety and tolerability of intravenous 131I-IPA administered concomitantly to 2nd line XRT in recurrent GBMSecondary objectives:- To assess the maximum tolerated dose (MTD) of 131I -IPA administered concomitantly to…
Main objective:The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. Thisevaluation will follow a…
Determine whether early postoperative treatment results in a longer survival without further treatments and in the end a longer overall survival, and whether earlier treatment results in the earlier occurence of delayed adverse effects of treatment
Primary Objective: The present study aims to generate detailed molecular characterization of paired tumor samples (i.e. obtained at first operation and at the time of tumor recurrence) of patients with glioma, with specific interest for at least 100…
Primary objective To evaluate the Overall Response Rate (CR/PRrate) in patients treated with pembrolizumab for recurrent or progressive PCNSL after MTX-based first-line therapy To evaluate the safety of pembrolizumab in subjects diagnosed with…