11 results
To test whether extremely hypofractionated radiotherapy (6 x 6 Gy) is non-inferior to standard radiotherapy (30 x 2 Gy) in terms of overall survival in patients with newly diagnosed GBM. Secondary objectives are to establish and compare health…
To determine if re-irradiation in 4 fractions is non-inferior to 10 fractions in the primary endpoint of survival after re-irradiation. Secondary objectives are to establish and compare health related quality of life (HRQoL), recurrence patterns,…
Implementation of liquid biopsy by NGS in cell-free circulating tumor DNA in CSF and / or blood, in patients clinically suspected of leptomeningeal metastases and / or brain metastasesDemonstrate that the detection of additional tumor mutations in…
To determine whether metabolic imaging at 7 Tesla is feasible and suitable to detect changes in phospholipids and APT levels in paediatric brain tumours.
This study has been transitioned to CTIS with ID 2024-514917-36-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Rx-induction: Comparison of the 3 year EFS rate of 2 induction regimens, GPOH and RAPID COJEC, in patients with high-…
To investigate the efficacy of bCBT compared to usual care in severely fatigued patients with primary brain tumors.
The current standard treatment for glioblastoma is a combination of surgery, radiation therapy (abbreviated RT), and temozolomide (abbreviated TMZ). The purpose of this study is to test the safety (any good or bad effects) of CC-90010 when combined…
This study has been transitioned to CTIS with ID 2024-512961-15-00 check the CTIS register for the current data. Primary:• The primary objective of the study is to demonstrate the efficacy of vorasidenib based on radiographic progression-free…
Identify if dexamethasone treatment alters the frequency and functionality of atypic B cells in blood.
In preparation of a randomized controlled trial, we aim to assess pilot data on technical feasibility and safety of LITT and to assess practical feasibility of a randomized study in patients with primary irresectable glioblastoma, as compared with…
To characterize glioma and epileptogenic tissue with 7T metabolic MRI, and validate their metabolic imaging characteristics with histopathological measures.