125 results
We aim to investigate the renal hemodynamic effects of empagliflozin in people with either preserved or impaired renal function with T2DM and people with impaired renal function without T2DM, all with and without adenosine blockade.
The aim of this study is to evaluate the: 1) prevalence of structural (urethral strictures) and 2) functional urethral complications (LUTS, abnormal uroflow characteristics and increased post void residual (PVR) volume) in boys post IUC placement.
(1) To develop patient-specific hemodynamic models of arteriovenous grafts at multiple time points after surgery, thereby including venous outflow stenosis; (2) to determine the critical stenosis severity at which the arteriovenous graft is at risk…
Primary objective:To deliver an easy accessible, patient friendly and low-cost self-help intervention for the treatment of depressive symptoms in dialysis patients.Main hypothesis: An eHealth CBT intervention reduces depressive symptoms in dialysis…
This project will be subdivided into three sections:Part I. Comparison of the ESM vs. SR-BDs and other retrospective questionnaires in the assessment of urological complaints in OAB such as urgency. Part II. Validation of new patient-reported…
Objectives: 1. To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional…
To investigate the prevalence of APOL1gene in patient on dialysis in the the Netherlands and correlate them to clinical parameters
The main goal is to define whether macrophages from patients with AGN induce T-cell activation and migration due to their pro-inflammatory phenotype.
To compare salt taste and saliva characteristics in healthy volunteers and patients with CKD.
To evaluate the prevalence of C-TMA in patients presenting with TMA, either with coexisting conditions or not. Furthermore, (i) the diagnostic performance of an in-house developed ex vivo test, (ii) dynamics of complement measures during follow-up,…
To analyze how potassium handling, volume and sodium status change in stable anuric chronic hemodialysis patients (CKD-5D) in response to higher dialysate potassium.
This study has been transitioned to CTIS with ID 2024-517467-23-00 check the CTIS register for the current data. Primary objective: - To investigate the effect of additional levamisole in comparison with placebo from 4 weeks to 6 months after the…
Main objectives are to identify brain areas involved in sensation of bladder filling through fMRI during urodynamic measurements. Secondary goals are to assess the correlation between bladder filling and subjects* bladder sensations in combination…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease activity parameters in…
To accomplish this aim we will address the following objectives:1. Define kidney disease heterogeneity within and between families carrying heterozygous COL4A3/COL4A4 pathogenic variants and evaluate hearing loss as non-renal phenotype;2. Analyze…
The primary objective is to determine whether iRVF patterns and renal damage/function are different in patients with a Fontan circulation compared to age and sex-matched healthy controls.The secondary objectives are to- Identify the prevalence of…
The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…
To assess kidney oxygenation in obese, hyperfiltering adults with T2D before and after bariatric surgery for men and women separately determined by BOLD-MRI
Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…
The main goal of this study is to explore the pattern of physiologic and pathophysiologic cardiac recovery after a preeclamptic pregnancy compared to a normotensive pregnancy, up till 18 months PP.To study the link between placental acute atherosis…