125 results
The aim of this pilot study is to further unravel the pathophysiologic mechanism of NS-induced hypercholesterolemia which willfurther guide the treatment of patients with NS.Given the recent insights on PCSK9-ENaC inhibition, our hypothesis is that…
The primary objective is to study whether muscle mass, muscle strength and self-reported physical health differ between patients on conventional hemodialysis and those on nocturnal hemodialysis. The second objective is to evaluate whether muscle…
Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…
We want to map the entire bacterial ecosystem in the gastrointestinal tract of patients with IgA nephropathy, in order to gain insight into the processes that may play a role in the development of the disease. This can then lay the foundation for…
The primary objective of this study is to describe the immunohistochemical characteristics of the bladder wall and urethra and to investigate possible microanatomical connections between nerves, ganglia and interstitial cells in the human bladder.…
Aim of the study is to assess1) the prevalence of glomerular dysfunction and tubular dysfunction in childhood cancer survivors treated with possible nefrotoxic therapy.2) the treatment related risk factors for glomerular and/or tubular dysfunction…
Primary Objective: - to investigate health-related quality of life (HRQoL) of patients surviving 2 years or more after the first cycle of an immune checkpoint inhibitor for melanoma or NSCLC.Secondary Objectives:- to assess neurocognitive function,…
To investigate how acute potassium administration affects potassium and sodium balance in healthy subjects as compared to patients at different CKD stages, i.e., normal kidney function and stage 3b/4 CKD.
1) To isolate and cryopreserve human primary bladder muscle and urothelial cells from women with isolated UUI so that we can validate the results from the molecular landscape in vitro.2) To collect and store human bladder biopsy tissues from women…
Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.
1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…
To clarify the mechanism of azoospermia in male cystinosis patientsTo determine the cause of azoospermia in male cystinosis patients as obstructive or non-obstructive by non-invasive means (clinical examination, reproductive hormonal profile,…
To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.
1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…
Primary ObjectiveThe primary objective of the current project is to study the association between biomarkers for renal mitochondrial damage in sepsis with the change in renal function and mortality after sepsis.Secondary Objective(s)The secondary…
The aim of this study is to compare glomerular filtration rate (GFR) in very long-term TC-survivors treated with chemotherapy, radiotherapy or surgery only and non-cancer treated healthy controls. Furthermore, a secondary aim is to assess prevalence…
More knowledge on immunity to VZV in these patient groups is necessary to be able to design preventive strategies to VZV infections in the future. To reach these goals, the proposed study is divided into two parts. The first part aims to determine…
Objectives: The main objective is to study renal tissue in relation to renal function before and after nephrectomy with a specific focus on microvascular structure and function. A second objective is to study renal microvascular alterations in…
Primary Objective: * Study the relationship between the pre-transplant plasma oxalic acid level and the risk of oxalate deposition in for cause renal transplant biopsies within 6 months after renal transplantation. Secondary Objective(s): * Track…
Primary objective is to design a non-invasive, bedside monitoring strategy for early detection of renal graft hypoperfusion after pediatric kidney transplantation, using transabdominal ultrasonography and biomarker surveillance in serum and urine.…