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Individual albuminuria lowering response to dapagliflozin in a decentralized
clinical trial in patients with type 2 diabetes mellitus and elevated albuminuria

Primary: To determine the individual response to the SGTL2 inhibitor dapagliflozin in urine albumin-to-creatinine ratio (UACR) Secondary:- To determine the individual response to the SGLT2 inhibitor dapagliflozin in: - Systolic blood pressure - Body…

An open-label study to assess the pharmacokinetics and safety/tolerability of pulsatile intra-vaginal delivery of a single dose of oxybutynin in healthy females

Primary* To evaluate the pharmacokinetics of oxybutynin and its main hepatic metabolite N-desethyloxybutynin after pulsed intra-vaginal delivery of a single dose of oxybutyninSecondary* To assess the safety and tolerability of the intra-vaginal…

Functional Renal Hemodynamics in Patients with Renal Artery Stenosis 3

To study the clinical value of pressure and flow assessment for predicting treatment response to PTRA and validate the pressure gradient assessment by CFD in patients with available CT angiography.

A study of non-invasive diagnostic techniques in renal osteodystrophy: 18F-sodiumfluoride positron emission tomography and serum non-oxidized PTH compared to bone histomorphometry

To assess accuracy of 18F-sodiumfluoride (NaF) positron emission tomography (PET) and serum non-oxidized parathyroid hormone (PTH) as an accurate, reliable and easy applicable diagnostic tools for the assessment of bone turnover in chronic kidney…

EFFECTS OF ANTIBODY REMOVAL BY IMMUNOADSORPTION ON THE IMMUNE PHENOTYPE IN PATIENTS WITH ANTIBODY MEDIATED DISEASES - A *TARGET-TO-B* STUDY

1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…

A single-center, prospective, placebo-controlled, double-blind, randomized, cross-over mechanistic intervention study to investigate the effect of empagliflozin on kidney function in people with either preserved or impaired kidney function with or without type 2 diabetes

We aim to investigate the renal hemodynamic effects of empagliflozin in people with either preserved or impaired renal function with T2DM and people with impaired renal function without T2DM, all with and without adenosine blockade.

An Open Label, Phase 1/2a Trial to Evaluate the Efficacy, Safety, and Tolerability of KU002 Given as Intravesical Instillations in Subjects with Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)*

Primary Objective:The primary objective of this study is to evaluate the safety, tolerability and PK profile following intravesical administration of KU002 in subjects with a diagnosis of BPS/IC.Secondary Objective(s):The secondary objective of the…

Effectiveness of drainage of the kidney by percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease caused by uroithiasis.

The primary objective is to assess whether a PCN is non-inferior to double J catheter regarding time to clinical recovery in patients with obstructive kidney disease resulting from urolithiasis.As the secondary objective we would like to investigate…

An Open-label, Randomized, Phase 3 Study of MK-6482 in Combination with Lenvatinib (MK-7902) vs Cabozantinib for Treatment in Participants with Advanced Renal Cell Carcinoma Who Have Progressed After Prior Anti-PD-1/L1 Therapy

This study has been transitioned to CTIS with ID 2024-510620-39-00 check the CTIS register for the current data. To compare belzutifan+lenvatinib to cabozantinib with respect to PFS per Response Criteria in Solid Tumors (RECIST) 1.1 as assessedby…

Plasma oxalate and glycolate levels in patients with chronic kidney disease (CKD stage 4 and 5).

The aim of this study is to establish reference values for plasma oxalate and plasma glycolate levels in patients with chronic kidney insufficiency. Values in patients with PH and secondary hyperoxaluria will be compared to values measured in…

Revised dosing recommendations of ciprofloxacin for patients with impaired renal function: a bioequivalence study.

This study has been transitioned to CTIS with ID 2024-520379-28-00 check the CTIS register for the current data. To compare exposure to ciprofloxacin between patients with impaired renal function (eGFR < 30 ml/min/1.73m2) admitted to a…

Phase 2 Study of MK-6482 in Participants With Advanced Renal Cell Carcinoma

This study has been transitioned to CTIS with ID 2022-502123-21-00 check the CTIS register for the current data. To compare the 120 mg once daily (QD) dose and 200 mg QD dose of MK*6482with respect to objective response rate (ORR) based on Response…

Normothermic Machine perfusion: an additional value for kidney transplant outcomes?

The aim of the current study is two-folded. The primary aim is to assess the impact of NMP on the incidence of PNF/DGF. Secondly, we investigate the association between microcirculation and oxyhaemoglobin during NMP as measured with the MoorO2Flo…

A multi-center, randomized, double-blind, placebocontrolled, parallel group, phase III study to
evaluate the efficacy and safety of LNP023 in primary IgA nephropathy patients

This study has been transitioned to CTIS with ID 2024-511067-29-00 check the CTIS register for the current data. The purpose of the study is to evaluate the efficacy and safety of LNP023 compared to placebo on proteinuria reduction and slowing renal…

A randomized, double-blind, parallel group, placebo-controlled, multi-center study to assess the safety and tolerability of monthly subcutaneous administrations of a low and high dose cohort of Osocimab to ESRD patients on regular hemodialysis.

In this study researchers want to learn about the safety of drug Osocimab at low and high doses in adult participants with kidney disease undergoing regular dialysis. Patients with kidney disease undergoing regular dialysis are at high risk for…

The evaluation of the influence of the use of total blood volume measurement during dialysis on the incidence of intradialytic hypotension associated events

The aim of current research is to re-investigate the utility of the above-described method and to confirm the hypothesis of a critical threshold of 65 ml blood volume per kg dry weight.

Angiotensin inhibitors during the perioperative period: to withdraw or to continue?

The objective of the proposed trial is therefore to determine the effect of continuation versus withdrawal of ACEi and ARB in the perioperative period on postoperative complications, expressed as acute kidney injury, myocardial injury, and quality…

the prevalence of APOL1 high risk alleles in dialysis population in the Netherlands

To investigate the prevalence of APOL1gene in patient on dialysis in the the Netherlands and correlate them to clinical parameters

Scope change in vasculitis: the role of monocytes and macrophages in ANCA-associated glomerulonephritis

The main goal is to define whether macrophages from patients with AGN induce T-cell activation and migration due to their pro-inflammatory phenotype.

Determinants of salt taste in healthy volunteers and patients with chronic kidney disease

To compare salt taste and saliva characteristics in healthy volunteers and patients with CKD.