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Prevention of renal and bladder damage in children with spina bifida by means of early injections with Botulinum-Toxin-A (Botox): a pilot study.

- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) prevent deterioration of the bladder and renal function?- Can early Botox-injections in the bladder of patients with meningomyelocèle (MMC) decrease the need for an…

A multi- center, randomized, cross-over study to demonstrate the efficacy of pudendal neuromodulation for the treatment of neurogenic overactive bladder

The purpose of this trial is to demonstrate the superior efficacy of pudendal neuromodulation in treating patients with neurogenic overactive bladder, who have failed conservative treatment, in a randomized cross-over trial.Symptoms of urinary…

A randomised controlled trial comparing physiotherapy to electromagnetic stimulation for urinary incontinence

Primary objective:Subjective improvement of urinary incontinence (PGI-I)Secondary objectives:Objective (using stress test, padtest, bladder diaries, Sandvik score) and subjective cure of incontinence (questionnaires)Complicaties en de novo…

Pharmacokinetics of nitrofurantoin in the elderly

The primary objective of this study is to provide an updated pharmacokinetic profile of orally administered nitrofurantoin in women aged 55 to 75 years.

Is Uracyst effective to prevent or reduce acute radiation cystitis in patients who are treated with radiotherapy for gynaecologic malignancy?

The goal of the study is to find out whether micturition complaints are prevented or reducted by the bladder instillations with Uracyst and secondly if it has a positive effect on painscores and micturition related quality of life.

An observational study on the effect of acupuncture with electric stimulation in multiple sclerosis patients with bladder dysfunction.

The research question which needs to be answered is: Is it feasible to recruit in 6 months a minimal of 20 patients with MS and bladder dysfunction to participate in an acupuncture study and are these patients compliant with the treatment and the…

Urodynamic changes after placement of the NeoTract® UroLift® System

The purpose of this study is to measure changes in urodynamic parameters during pressure flow studies before and after the UroLift treatment and try to identify which of these parameters may be responsible for the symptomatic response. We…

Evaluation of the patients* satisfaction and safety of a non-degradable urethral bulking agent for female stress urinary incontinence

Primary Objective: To determine the subjective improvement of symptoms in women with SUI treated with PDMS (Urolastic®)Secondary Objectives: - To determine the patients* satisfaction- To determine the complications and re-intervention rate- To…

Shorter treatment of catheter-related urinary tract infections

The primary objective is to establish the non-inferiority of treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days, as compared to the standard duration of 10 days of therapy. Secondary objectives…

A nationwide multicentre, open-label study of six months avelumab maintenance treatment in patients with locally advanced or metastatic urothelial cancer whose disease did not progress after at least 4 cycles of first-line platinum-containing chemotherapy and the opportunity to re-treat

This study has been transitioned to CTIS with ID 2024-512975-11-01 check the CTIS register for the current data. To demonstrate benefit of maintenance treatment with avelumab for a maximum of six months avelumab in increasing overall survival (OS)…