115 results
1. To explore the pharmacokinetics (PK) of intra-vaginal delivery of gonadorelin and oxybutynin. 2. To assess the safety and tolerability of gonadorelin and oxybutynin delivery with a prototype intra-vaginal ring.
Primary objective: to study potential risk factors for post-operative urinary retentionsecundary objective: construction of a risk calculator to identify patients at risk for post-operative urinary retention
The purpose of the study is to investigate how quickly and to what extent AQX 1125 in the tablet form and the capsule form are absorbed and eliminated from the body (this is called pharmacokinetics). The pharmacokinetics of AXQ 1125 after…
The main objective of the study is to construct reference curves for fetal bladder diameters and volume in the second and third trimester of pregnancy. Moreover we will investigate the variation in the dimensions of renal pelvis in relation to the…
The purpose of this study is to measure changes in urodynamic parameters during pressure flow studies before and after the UroLift treatment and try to identify which of these parameters may be responsible for the symptomatic response. We…
This study will evaluate usability, safety and performance of a cystoscopic guided injection of a marker (BioXmark) at the tumor site in patients with bladder cancer on planning CT and CBCT during the irradiation period.
Primary Objective: To determine the subjective improvement of symptoms in women with SUI treated with PDMS (Urolastic®)Secondary Objectives: - To determine the patients* satisfaction- To determine the complications and re-intervention rate- To…
The primary objective is to establish the non-inferiority of treating a symptomatic urinary tract infection in patients with a long-term indwelling catheter for 5 days, as compared to the standard duration of 10 days of therapy. Secondary objectives…
to investigate barriers and facilitators of implementation of an e-health intervention for the treatment and guidance of Dutch women with SUI, as well as its effect on incontinence severity and quality of life.
Treatment of REfractory Overactive BLadder with the AXonics Sacral Neuromodulation System:
RELAX-OAB
The RELAX-OAB is a post-market clinical follow-up (PMCF) study designed to confirm the safety and technical performance of the Axonics Sacral Neuromodulation (SNM) System as an aid in the treatment of the symptoms of overactive bladder (OAB). The…
The primary objective of the entire study is to compare rogaratinib (BAY1163877) with chemotherapy (docetaxel, paclitaxel or vinflunine) in terms of prolonging the Overall survival (OS) of patients with FGFR positive urothelial carcinoma.
To directly correlate CLE images with histopathology, and identify and define CLE characteristics of normal urothelium, benign bladder urothelium, and bladder tumors (low-grade, high-grade NMIBC or CIS) of the lower urinary tract.
In this study, the aim is to perform a clinical evaluation of the NovioMini in children during (video) urodynamics to examine the performance of the NovioMini over a wider range of bladder volumes and to determine if these is a relation between the…
Primary study objective is to prospectively assess whether the presence of CTCs in the peripheral blood of non-metastatic MIBC patients can identify patients with such a good prognosis not justifying neoadjuvant chemotherapy. Secondary study…
Primary Objective: This study is set up to validate the patient comfort of the current design of the FemFlow. For the validation of the patient comfort, the FemFlow will be rated on:Comfort during insertion Comfort of an alien object in the bladder…
Determine the efficacy and safety (using objective response rate) of tremelimumab in patients with advanced solid tumors (UBC, PDAC, TNBC).
In this study, the aim is to perform a home based evaluation of the SENS-UTM Bladder Sensor during the night to examine the usability of the SENS-UTM for ambulatory care in children with nocturnal enuresis.
The main objective is to evaluate the average time span within which *time of onset* and *time of offset* occurs in patients with overactive bladder syndrome or non-obstructive urinary retention who respond to SNM.
Primary* To evaluate the pharmacokinetics of oxybutynin and its main hepatic metabolite N-desethyloxybutynin after pulsed intra-vaginal delivery of a single dose of oxybutyninSecondary* To assess the safety and tolerability of the intra-vaginal…
The aim of the project is to investigate whether the Nova contributes to cost-effective, client-oriented incontinence care for people with a profound disability, based on a cluster randomized study with a waiting list control group and a pragmatic…