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Optimal Stimulation Rates in Sacral Neuromodulation Therapy

To determine whether rate change is feasible and has a positive influence on the effect of SNS on the symptoms measured with voiding diaries.To investigate whether there are differences between optimal stimulation settings between patients with SNS…

Randomized, double-blind, placebo-controlled, parallel group study of vardenafil 10 mg twice daily to assess the effect on urodynamics in patients with Overactive Bladder (detrusor overactivity).

To determine the therapeutic effect of vardenafil 10 mg taken twice daily (BID) on Overactive Bladder by means of urodynamic measurements (filling cystometry and pressure flow investigations).

A randomized controlled trial of anterior colporraphy and PerigeeTM as surgical correction of symptomatic cystocele.

To study which technique is most effective to surgically correct a symptomatic cystocele.2. To compare morbidity and post-operative recovery of anterior colporraphy and PerigeeTM.3. To compare the need for repeated pelvic floor surgery following…

Performance of the miniaturo*-I system for treatment of urinary urge incontinence.

To determine the performance (safety and effectiveness) of miniaturo*-I for the treatment of urinary urge incontinence.

Functional effects of treatment of organ confined prostate cancer on lower urinary tract

1-objective: to get insight in objective (urodynamic) and subjective (questionnaire) changes of the lower urinary tract after laparoscopic robot assisted radical prostatectomy, Intensity modulated radiotherapy, I-125 brachytherapy.2-To create…

Muscarinic receptor genotype

Objective: To determine whether genotype of the promoter polymorphism is associated with alterations of mRNA expression of the M2 receptor

A Phase II, international, multi-centre, prospective, randomised, parallel-group, double-blind, dose-ranging, placebo-controlled, 12-week, princeps study to assess the efficacy and safety of a one injection cycle with either botulinum toxin type-A (Dysport® 125, 250 or 500 units) or placebo followed by an optional 6-month extension phase in the symptomatic treatment of micturition urgency and frequency in continent female subjects suffering from idiopathic overactive bladder.

Primary Objective: To assess the effect of treatment with three doses of botulinum toxin type-A (Dysport®) versus placebo on the number of episodes of urgency and frequency of micturition experienced in continent female subjects with idiopathic…

A randomized, double-blind, placebo-controlled, parallel-group, multi-centre, Phase IIb, study to determine the effect of BXL628 in women with detrusor overactivity

the primary objective is to evaluate the effect of BXL628 on the bladder volume at the first involuntary contraction following 4 weeks of treatment; the secondary objectives are to determine the effect of BXL628 on symptom severity measured by a…

Is Uracyst effective to prevent or reduce acute radiation cystitis in patients who are treated with radiotherapy for gynaecologic malignancy?

The goal of the study is to find out whether micturition complaints are prevented or reducted by the bladder instillations with Uracyst and secondly if it has a positive effect on painscores and micturition related quality of life.

An observational study on the effect of acupuncture with electric stimulation in multiple sclerosis patients with bladder dysfunction.

The research question which needs to be answered is: Is it feasible to recruit in 6 months a minimal of 20 patients with MS and bladder dysfunction to participate in an acupuncture study and are these patients compliant with the treatment and the…

One day versus three day suprapubic catheterisation after vaginal prolapse surgery: a randomized controlled trial.

To determine the optimal moment to start bladder training after vaginal prolapse surgery with anterior colporrhaphy.

Molecular diagnostics of bladder cancer.

Previous research demonstrates that in some cases, where the tumor of the patient contains a mutation in FGFR3, the mutation can not be detected in urine derived from the same patient. Our hypothesis states that this urine does not contain any tumor…

12-week, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, multicenter trial to evaluate the efficacy and safety of fesoterodine in comparison to tolterodine ER in patients with overactive bladder.

To compare the efficacy of fesoterodine to placebo and tolterodine ER in subjects with overactive bladder after 12 weeks of treatment.

Evaluation of the Transversus abdominis plane block (TAP-block) in preventing painful urine bladder spam in patients undergoing Robot Assisted Laparoscopic Radical Prostatectomy under general anesthesia, a prospective randomized controlled trial

To evaluate the value of a TAP-block for the reduction of postoperative bladder spasm after RALP for prostate cancer

A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Safety and Efficacy of a Single Treatment with Two Dose Levels of BOTOX?? (Botulinum Toxin Type A) Purified Neurotoxin Complex Followed by a Treatment with BOTOX?? in Patients with Urinary Incontinence Due to Neurogenic Detrusor Overactivity

Objective: The principal objective is to evaluate the safety and efficacy of two doses of BOTOX (200 Units or 300 Units) compared with placebo injected into the bladder wall in patients who have urinary incontinence due to neurogenic detrusor…