183 results
Main study:Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the GLP-1RA versus a single dose prandial insulin onrenal hemodynamics (glomerular filtration rate/ effective renal plasma flow in basal insulin-…
1. to determine the feasibility and acceptability of an e-supported lifestyle coaching program and2. to assess the effects of personalized lifestyle support in patients with insulin dependent type 2 diabetes mellitus immediately after 12 weeks and…
to develop standardized tubular function tests with reference intervals/values.
The study has 3 objectives: 1. Proving that this form of RCA does not increase the risk of bleeding while achieving a degree of anticoagulation of the extracorporeal system that is similar to that when using LMWH. When this study shows that citrate…
To study the efficacy, adverse events, logistic feasibility and costs of immunoadsorption for the removal of anti-GBM antibodies in patients with acute renal failure due to anti-GBM glomerulonephritis.
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
The main goal of the current study is to confirm the origin of this sympathetic signal and compare it to the response in healthy humans. Secondly the goal is to assess the extent to which the suggested renal pressor response in CKD can be reversed.
To assess intra- and interpatient variability of plasma Mg concentration before and after hemodialysis.
To measure changes in urinary RAS components during an acid-loading test in patients with CKD and healthy controls.
Collect data in an observational study on outcomes of endovascular fistula creation using the everlinQ endoAVF System
to determine the normal FGF23 response in case of hypophosphatemia
to determine if there is an alternative mechanism for urine acidification in men in response to furosemide other than that through ENaC
Primary Objectives: 1. To assess the prevalence of AAV related damage in AAV, i.e. cardiovascular damage and impaired QOL.Secondary objectives2. To assess whether there exists an association between cardiovascular disease, QOL and disease activity…
to determine the prevalence and significance of chronic nephrotoxic effects of cisplatin therapy by 1) identifying patients with chronic cisplatin nephrotoxicity and 2) reviewing their QoL. Eventually, this could improve care in these patients
In this single center cohort study the primary objective is to assess minimal residual autoimmunity (MRA) in RTX treated AAV patients. The primary objective is to routinely assess the composition of the memory B-cell and plasma cell compartment…
The objective of this study is to investigate the role of inflammatory mediators (circulating platelet activity levels, MP numbers, and levels of plasma/urinary mtDNA) to the occurrence and severity of acute rejection and renal outcome.
The main objective is to study the effect of renal transplantation with a living donor on selected cardiovascular, nutritional and activity parameters in both recipients as well as living donors.
1. To evaluate if podocytes directly cultured from the urine, and podocytes derived from induced pluripotent stem cells (iPSCs), can be used to prove causality of the VUS.2. Comparison of results obtained using iPSC-derived and urinary podocytes,…
Primary objective* To investigate the correlation between cutaneous microcirculation (using LSCI), finger and toe pressures and shunt flow in hemodialysis patients.Secondary objectives* To investigate the variability in basal flow measured with LSCI…
See protocol P5:The primary objective of this study is to evaluate the efficacy of 12 months of oral ACH-0144471 in participants with C3G or ICMPGNbased on histologic scoring and proteinuriaThe secondary objectives of this study are: * To evaluate…