183 results
The aim of our study is to compare outcomes between start of dialysis with higher renal function versus lower renal function and start of dialysis with a few signs and symptoms versus many signs and symptoms, to determine a valid method to measure…
Primary objectives:To perform a study to:1. Estimate the prevalence of elevated albuminuria in subjects with a high risk of chronic kidney disease in the Netherlands.2. Evaluate which screening approach would be most effective based on costs per…
Main objectives: 1 Perform regression and correlation analysis on urea concentrations in sweat/saliva versus blood at the start of hemodialysis (C0), at the end of hemodialysis (Ct) and on the ratio (Ct/C0). 2 Feasibility of sweat and/or saliva…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease activity parameters in…
To accomplish this aim we will address the following objectives:1. Define kidney disease heterogeneity within and between families carrying heterozygous COL4A3/COL4A4 pathogenic variants and evaluate hearing loss as non-renal phenotype;2. Analyze…
To examine the effect of a multi-modal prehabilitation program on frailty and other indicators of physical and psychological fitness of KTCs during the waiting-list period and its optimal implementation in a real-world situation.
The primary objective is to determine whether iRVF patterns and renal damage/function are different in patients with a Fontan circulation compared to age and sex-matched healthy controls.The secondary objectives are to- Identify the prevalence of…
Primary objectives: - Describe the safety of daprodustat, overall (all ages) and in each age group.Secondary objectives:- Describe changes in other parameters relevant to safety, overall and in each age group.- Describe the effect of daprodustat on…
Primary:Evaluate the impact of SoC anemia management on Hgb concentrationsSecondary:- Characterize the use of ESA therapies in management of anemia associated with moderate to severe CKD in children and adolescents aged <18 years- Evaluate…
Primary Objective: to show a reduction in eGFR decline in patients treated with LCP tacrolimus compared to IR tacrolimus. Secondary objectives will include investigating the potential decline in other known side effects of calcineurin inhibitors i.e…
Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…
Could cytokines removal therapy by CytoSorb adsorber cause any improvement in the microcirculation?
The primary objective of this study is to investigate the effect of lifestyle and dietary habits on outcomes in patients with type 2 diabetes mellitus.
The aim of this pilot study is to further unravel the pathophysiologic mechanism of NS-induced hypercholesterolemia which willfurther guide the treatment of patients with NS.Given the recent insights on PCSK9-ENaC inhibition, our hypothesis is that…
The primary aim of the study is to improve microvascular endothelial health after 3 months expressed by the Microvascular Healt Index, using a non-invasive imaging technique, upon two different dietary interventions compared to the placebo. The…
Primary Objective:To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are increased in patients with T2D who have macroalbuminuria as compared to patients with normoalbuminuria.Secondary…
- To evaluate the effect of magnesium and phosphate supplementation on intracellular levels of magnesium and phosphate determined with different techniques.- To determine if symptoms are related to intracellular levels of magnesium or phosphate.
The main objectives are:• To assess canagliflozin target (i.e. receptor) specific binding in vivo• To assess receptor occupancy of canagliflozin in vivo• To determine optimal scanning time in vivoTo explore the relationship between canagliflozin…
We want to map the entire bacterial ecosystem in the gastrointestinal tract of patients with IgA nephropathy, in order to gain insight into the processes that may play a role in the development of the disease. This can then lay the foundation for…
A better understanding on the individual response to different albuminuria lowering drugs and a better understanding why these drugs, of which some are developed for another indication, may help to tailor optimal therapy. Therefore in this study…