50 results
Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…
The aim of this pilot study is to further unravel the pathophysiologic mechanism of NS-induced hypercholesterolemia which willfurther guide the treatment of patients with NS.Given the recent insights on PCSK9-ENaC inhibition, our hypothesis is that…
We want to map the entire bacterial ecosystem in the gastrointestinal tract of patients with IgA nephropathy, in order to gain insight into the processes that may play a role in the development of the disease. This can then lay the foundation for…
To investigate how acute potassium administration affects potassium and sodium balance in healthy subjects as compared to patients at different CKD stages, i.e., normal kidney function and stage 3b/4 CKD.
Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.
1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…
To clarify the mechanism of azoospermia in male cystinosis patientsTo determine the cause of azoospermia in male cystinosis patients as obstructive or non-obstructive by non-invasive means (clinical examination, reproductive hormonal profile,…
To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.
1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…
Primary objective is to design a non-invasive, bedside monitoring strategy for early detection of renal graft hypoperfusion after pediatric kidney transplantation, using transabdominal ultrasonography and biomarker surveillance in serum and urine.…