252 results
The aim of this trial is to study if physical performance improves and protein energy wasting decreases in patients who change from conventional hemodialysis to nocturnal hemodialysis, compared to patients who continue their treatment on…
The effect of correction of metabolic acidosis in chronic kidney disease on intrarenal RAS activity.
Primary Objective: - To study if sodiumbicarbonate therapy in patients with metabolic acidosis due to chronic kidney disease diminishes intrarenal RAS activity (without affecting the systemic RAS).Secondary Objective(s): - To study if…
To compare the antiproteinuric effects of sacubitril/valsartan (ARNI) and valsartan (ARB).
The specific objectives of the SCOPE project will be:O1. to assess existing methodologies for CKD screening among older adults using real-life data from a cohort of 75+ older patients; O2. to investigate novel and potentially useful application of…
Primary Objective:* To demonstrate the safety of intravenous (i.v.) iodinated iso-osmolar iodixanol (Visipaque* Injection 320 mgI/mL) usage in contrast-enhanced computed tomography (CECT) for CKD stage III/IV patients by evaluating the incidence of…
Primary objective is to design a non-invasive, bedside monitoring strategy for early detection of renal graft hypoperfusion after pediatric kidney transplantation, using transabdominal ultrasonography and biomarker surveillance in serum and urine.…
In this pilot study, we aim to validate MR-measurement of GFR to gold standard clearance measurements in subjects with a range of different GFRs: namely chronic kidney disease (CKD) patients, hypertensive patients and healthy subjects.
are sildenafil, metformin and simvastatin effective in stimulation of ADH independent urine concentration in man?
Primary objective: to investigate the effect of amiloride on urine volume and urinary concentrating ability in patients on chronic lithium therapy suffering from polyuria.We hypothesize that amiloride therapy will improve urinary concentating…
The Primary objective is to determine whether the administration of ACH 0144471 can increase C3 levels in patients with low C3 levels due to either C3G or IC-MPGN.The secondary objectives are:* To evaluate the safety and tolerability of ACH 0144471…
In this study, we aim to improve the genetic diagnosis of patients with genetic renal tubulopathy-related disorders. We hypothesize that a higher diagnostic yield can be obtained by genetic re-screening of patients using the updated renal gene panel…
The primary objective of the study is to assess the longitudinal effects of differences and changes in renal function at CKD stage 3-5 on physical functioning. The secondary objectives of the study are to assess the longitudinal effects of…