252 results
Assess the efficacy and safety of eculizumab in pediatric patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
Assess the efficacy of eculizumab in adult patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
Primary Objective:Determination of the best surgical approach in the individual patient to achieve optimal outcome statistics (catheter survival, 30-day or in-hospital mortality and long-term mortality) Secondary Objective:Comparison of short and…
The primary question is whether certain tubular biomarkers are associated with albuminuria. It is thougt that to much albumin in the pre-urine is toxic to the proximal tubulus. By measuring different kind of damage markers of different locations of…
In this trial we will investigate the following hypothesis:- Uremic vasculopathy develops, not only in large and medium sized conduit vessels, but also in the microcirculation.- There is a relationship between the rate of microcirculatory…
the study aims to answer the following question:are components of innate immunity in general, and the complementsystem in particular, correlated with and usefull as predictors for the occurrence of macro- and/or microvascular complications in a high…
The aim of the study is to improve the quality of life of cystinosis patients. Part of it forms neuropsychological screening in order to identify specific defects in the neurocognitive development and learning abilities. The results will contribute…
Our primary objective is to investigate if the previously found MSNA is related to the presence and severity of CV organ damage quantified as left ventricular mass, independent of other CV risk factors. We hypothesize that despite of treatment…
To improve the quality of care for children with End Stage Renal Disease by central registration and frequent intervision.
The primary objective is to investigate if there is an incremental inhibiting effect on MSNA by increasing dosage valsartan above the presently advised dosage. We hypothesize that there will be a further decrease in MSNA as compared to the MSNA…
-To investigate whether a short-term treatment (3 months) with benfotiamine in diabetic nephropathy patients leads to a reduction in urinary excretion of β2-microglobulin and albumin.-To investigate whether short-term treatment (3 months) with…
The primary objective is to investigate if there is an incremental inhibiting effect on MSNA by increasing dosage valsartan above the presently advised dosage. We hypothesize that there will be a further decrease in MSNA as compared to the MSNA…
The major aim of this project is to elucidate the molecular basis of IgAN. A large cohort of IgAN patients will be screened on aberrancies in the DNA sequence or expression of the gene encoding Cosmc, a protein that is essential for the biosynthesis…
Primary: To prove that infliximab in combination with azathioprine is superior to azathioprine alone in rapidly inducing a meaningful renal improvement, defined as a reduction in preoteinuria of at least 50%, in patients with membranous SLE…
Study whether chloroquine as comedication results in a better respons on Hepatitis B vaccination in non-responder dialysis patients.
The primary objective of this study is to determine whether ACE inhibition results in an improvement of microvascular glycocalyx-thickness in patients with type 1 diabetes. The secondary objectives are to investigate whether this (hypothesized)…
To compare the accuracy of the measured GFR using bolus 51Cr-EDTA, and Gd DTPA, and estimated GFR using cystatin C and creatinine with the continuous 125I-labelled iothalamate infusion method.
Aim of the present study is to compare the effects of low-flux hemodialysis, post-dilution on-line hemodiafiltration, and superflux dialysis with regard to clearance and pre-dialytic levels of larger uremic substances. Moreover, the effects of these…
To determine the effect of rituximab, when added to standard immunsuppressive therapy, on the incidence and severity of biopsy-confirmed acute rejection within the first six months after transplantation.
The purpose of the study is threefold. First, to describe the course of quality of life after renal transplantation and to identify predictors of (un)succesful adjustment. Second, to investigate intra- and interindividual differences that influence…