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Immunomonitoring of minimal residual autoimmunity using highly sensitive flow cytometry in ANCA-associated vasculitis patients treated with rituximab.

In this single center cohort study the primary objective is to assess minimal residual autoimmunity (MRA) in RTX treated AAV patients. The primary objective is to routinely assess the composition of the memory B-cell and plasma cell compartment…

The role of inflammatory mediators (platelet activity,the number and origin of micro particles and levels of mitochondrial DNA) in patient with acute renal transplant rejection.

The objective of this study is to investigate the role of inflammatory mediators (circulating platelet activity levels, MP numbers, and levels of plasma/urinary mtDNA) to the occurrence and severity of acute rejection and renal outcome.

Treatment transitions in uremia:
A survey on the effects of transplantation on cardiovascular and nutritional state, and physical activity

The main objective is to study the effect of renal transplantation with a living donor on selected cardiovascular, nutritional and activity parameters in both recipients as well as living donors.

A phase 4, monocenter, randomized, double-blind, comparator-controlled, 3-armed parallel mechanistic intervention trial to assess the effect of 8-week empagliflozin (SGLT-2 inhibitor) monotherapy, followed by 8-week empagliflozin and linagliptin (DPP-4 inhibitor) combination therapy versus 8-week linagliptin monotherapy, followed by 8-week linagliptin and empagliflozin combination therapy versus 8-week gliclazide (Sulfonylurea derivate), followed by 8-week gliclazide intensification therapy on r

To examine the effects of mono- and combination therapy with linagliptin and empagliflozine on renal hemodynamics

Podocytes derived from induced pluripotent stem cells as biomarker of disease-causing mutations

1. To evaluate if podocytes directly cultured from the urine, and podocytes derived from induced pluripotent stem cells (iPSCs), can be used to prove causality of the VUS.2. Comparison of results obtained using iPSC-derived and urinary podocytes,…

The influence of hemodialysis and vascular access surgery on systemic circulation and microcirculation: a validation study

Primary objective* To investigate the correlation between cutaneous microcirculation (using LSCI), finger and toe pressures and shunt flow in hemodialysis patients.Secondary objectives* To investigate the variability in basal flow measured with LSCI…

Volatile Anesthetic Protection Of Renal transplants 2

To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on acute rejection and outcome in recipients of living, DCD and DBD donor kidneys.

An Open-Label Phase 2 Proof-of-Concept Study in Patients with C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Treated with ACH-0144471.

See protocol P5:The primary objective of this study is to evaluate the efficacy of 12 months of oral ACH-0144471 in participants with C3G or ICMPGNbased on histologic scoring and proteinuriaThe secondary objectives of this study are: * To evaluate…

Towards HOMe-based Albuminuria Screening: an implementation study testing two approaches

Primary Objective: To investigate whether population screening for increased albuminuria among the Dutch population can contribute to the early detection of yet undiagnosed risk factors for renal and cardiovascular diseases in an early stage. For…

Randomised, double-blind (within dose groups), placebocontrolled and parallel group trial to investigate the effects of different doses of oral BI 685509 given over 20 weeks on UACR reduction in patients with diabetic kidney disease

The main objectives of the trial are to demonstrate the effectiveness of BI 685509 and to characterize the dose-response relationship for BI 685509 in patients with DKD by assessing 3 doses and placebo.

SeMaglutide and Albuminuria Reduction Trial in obese individuals without diabetes

The main objective of the study is to assess the albuminuria lowering effects of semaglutide 2.4 mg s.c. once weekly (Semaglutide 3 mg/ml) compared to placebo in obese/overweight non-diabetic individuals with elevated albuminuria.

Individual albuminuria lowering response to dapagliflozin in a decentralized
clinical trial in patients with type 2 diabetes mellitus and elevated albuminuria

Primary: To determine the individual response to the SGTL2 inhibitor dapagliflozin in urine albumin-to-creatinine ratio (UACR) Secondary:- To determine the individual response to the SGLT2 inhibitor dapagliflozin in: - Systolic blood pressure - Body…

The effect of dietary salt intake on proximal tubular endocytic function

To investigate whether dietary salt intake influences proximal tubular endocytic function.

An integrated immunological-pharmacological approach to improve long-term allograft function

The main aims of the present study:1. Define the causality between low immunosuppression, i.e. high IPV, and anti-donor T-cell and B-cells immune responses2. Set a robust benchmark for CRAD3. Improve the knowledge of the biological mechanisms…

A study of non-invasive diagnostic techniques in renal osteodystrophy: 18F-sodiumfluoride positron emission tomography and serum non-oxidized PTH compared to bone histomorphometry

To assess accuracy of 18F-sodiumfluoride (NaF) positron emission tomography (PET) and serum non-oxidized parathyroid hormone (PTH) as an accurate, reliable and easy applicable diagnostic tools for the assessment of bone turnover in chronic kidney…

EFFECTS OF ANTIBODY REMOVAL BY IMMUNOADSORPTION ON THE IMMUNE PHENOTYPE IN PATIENTS WITH ANTIBODY MEDIATED DISEASES - A *TARGET-TO-B* STUDY

1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…

Open label multicentre randomized trial comparing standard immunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen in combination with everolimus in the novo renal transplantation in elderly patients.

This study has been transitioned to CTIS with ID 2024-516509-22-00 check the CTIS register for the current data. 1. To test the hypothesis that an age adapted immunosuppressive regimen targeted at reduced immunosuppression with low calcineurin…

The application of induced pluripotent stem cells to predict return of the same kidney disease after transplantation.

Development of a predictive test for r-FSGS at the individual level of a patient and kidney donor with FSGS.

A randomized, open-label, parallel group, two arm, proof-of-concept clinical trial to investigate the efficacy and safety of LNP023 compared with rituximab in the treatment of subjects with idiopathic membranous nephropathy.

The purpose of this study is to ascertain the efficacy, safety, tolerability and pharmacokineticsof LNP023 over a 24-week treatment period compared with rituximab in subjects with MN.

Preventing Oxidative stress-induced ischemic injury and systemic inflammation complications during and after invasive cardiac surgery with Alkaline Phosphatase (APPIRED III)

The purpose of this study (APPIRED III) is to investigate the efficacy of administered prophylactically RESCAP with regard to the prevention of (severe) renal failure, or renal dysfunction, reducing morbidity and mortality. It also looks at systemic…