296 results
Objective is to show equivalence with respect to the efficacy of sugammadex in subjects with normal or severely impaired renal function, to evaluate the safety of sugammadex in these subject groups and to compare the pharmacokinetic profiles.
Primary objective: To demonstrate superior renal allograft function in de novo renal transplant recipients after early CNI to everolimus conversion assessed by Glomerular Filtration Rate (eGFR) estimated by the Modification of Diet in Renal Disease…
Feasibility of laboratory monitoring in community pharmacies by Point-Of-Care testing creatinine and potassium in ambulatory elderly at risk for impaired renal function.
The main aim is to develop an intervention to change knowledge, communication and attitudes regarding renal replacement therapy (RRT). The second main aim is to investigate whether this intervention has an impact on the proportion of patients…
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
The purpose of the trial is to determine the effect of multiple doses of tolvaptan on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) at various stages of renal function. Additionally, the short-term renal…
To investigate if a dosage advice for darbepoetin and iron generated by a pharmacist leads to an increase of haemodialysis patients whose haemoglobin values lie within the target range, compared to dosage of darbepoetin by the nephrologist alone.
Primary objective:- To determine the clinical efficacy of multiple doses of 177Lu-DOTA-cG250 at MTD in patients with advanced renal cancer using RECIST criteriaSecondary objectives:- To determine the toxicity of the treatment as defined by NCI…
The primary objective of the study is to evaluate the feasibility of 89Zr-bevacizumab PET imaging as a biomarker before and during treatment with sunitinib or bevacizumab plus interferon in patients with RCC.
To investigate the safety and efficacy of a programmed introduction of a sirolimus based calcineurin inhibitor free maintenance immunosuppressive regime three months after renal transplantation in recipients of a non-heart-beating donor kidney graft…
The primary hypothesis of the study is that the use of icodextrin leads to a reduction in extracellular volume compared to glucose 2.27%, but that the effects of icodextrin and glucose 2.27% on plasma will not differ.
Primary: 1 to test the safety and feasibility of autologous MSC therapy in HLA-DR mismatched patients with SCR in the renal biopsy 4 weeks after renal transplantation.Secondary1 To assess histologic changes before and after MSC treatment.2 To…
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.
Assessment of the effect of kidney-pancreas transplantation in diabetic nephropathy patients on microvascular alterations using orthogonal spectral polarization and correlate this effect with markers for endothelial cell dysfunction and fibrosis
Primary objective: To assess the degree of tacrolimus over-exposure in renal transplant patients with mild diarrhea while on treatment with tacrolimus and mycophenolate mofetil.Secondary objective: To assess the intra-individual variability of…
1.1 What are the self-perceived symptoms and care needs of patients with moderate to very severe COPD, CHF or CRF and to what extent do they differ from each other?1.2 Do these self-perceived symptoms and care needs relate to patients* daily…
The objective of this study is to determine the accuracy of the Cockcroft-Gault and the MDRD formula as estimators of GFR in geriatric patients. Some other new methods for daily practice will be investigated as well (see primairy parameters).
The results of this study will give better insights in the role of ADMA in the development of systemic endothelial dysfunction.
To assess whether in renal transplant patients with tacrolimus OD taken in the morning measurement of the trough level can be delayed from the morning to the afternoon.
Objectives: A prospective, open label, randomized trial, in which we aim to achieve optimal immunosuppression after renal renal transplantation with maximal reduction of side effects, especially of vascular injury, chronic allograft nephropathy,…