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An open-label, single centre study to assess and compare the intra- and interpatientvariability in the oral bioavailability for Immediate-Release Tacrolimus and after conversion to Modified-Release Tacrolimus in stable kidney transplant recipients.

Primary objective: - evaluation and comparison of the intra- and interpatient variability for the Area under the curve (AUC) of orally administered Tac BID and Tac QD in stable renal transplant patients. Secondary objective: - evaluation and…

Hemodialysis-associated left ventricular dysfunction: identification of dialysis-induced triggers, prevalence and prognostic impact.

1. To establish the prevalence and prognostic impact of HD-associated LV dysfunction; 2. To identify (clues to) mechanisms/ pathways that are pathophysiologically involved in HD-associated LV function.

A randomised controlled trial comparing intra- uterine vesico- amniotic shunting vs. not shunting in the treatment of congenital bladder outflow obstruction.

ObjectiveA high-quality multi-centre randomised controlled trial (RCT) with the following objectives:Primary objective:• To determine if intrauterine vesico-amniotic shunting for fetal bladder outflowobstruction, compared to conservative, non-…