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POETIC: Point Of carE Testing for urinary tract Infection in primary Care:
Study Stages 3 & 4: Randomised controlled trial and post-RCT observational study

The overall aim of our study is to evaluate the management of suspected uncomplicated UTI in women presenting in primary care through use of a novel point of care test (POCT, Flexicult). This study is being carried out in 4 European networks: Wales…

Prevalence of overactive bladder (OAB) in patients with pelvic organ prolapse (POP) and predictors of symptoms of OAB after surgical correction of POP.

The primary aim of this research project is to investigate the prevalence and bother of OAB before and after POP repair surgery and to determine changes in bladder function after surgery. Secondary aim is to identify predictors of persistence,…

Relevance of Biomarkers and Clinical Predictors of Outcome in Unselected Population with Febrile Urinary Tract Infection at Primary Care and Emergency Department in a Prospective, Randomized Cohort Trial Comparing Short (7 days) Antibiotic Treatment with Conventional Treatment (14 days)

To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…

Uremic Toxins, Cardiovascular Effects and Physical Activity in Intensive Hemodialysis

The primary objective of this study is to compare vascular biology (vascular markers and endothelial microparticles) and cardiovascular effects (volume status, blood pressure, pulse wave velocity and microcirculation) in conventional hemodialysis (…

The feasibility of a physical activity program for men with lower urinary tract
symptoms and/or erectile dysfunction who show up at the OPD urology of the VU medical center with a lack of
physical activity.

1. determine how many male patients visiting the OPD urology for LUTS and/ or ED lack a certain amount of physical activity2. measure the willingness of those patients to follow a program for increasing their physical activity3. discover factors…

Asymptomatic Bacteriuria and Urinary Tract Infections in pregnant women with and without Diabetes Mellitus

What is the prevalence of ASB and incidence of UTIs during pregnancy in women with DM or GDM compared to pregnant women without diabetes? In addition, risk factors for ASB and UTIs, as well as consequences of ASB and UTIs will be investigated. These…

The central cause of overactive bladder, a pilot study

The objective of this study is to proof the presence of lesions in the brain of patients with overactive bladder and urge-incontinence (OAB wet) as a central cause of this disorder. This survey is a pilot investigation for a larger study on the…

Clinical parameters and biomarkers in blood and urine as predictors for bacteremia, hospital admission, morbidity and outcome in patients with complicated urinary tract infections.
A study in primary care, the medicine emergency room and ICunit.

Establish relevance of a clinical scoring system, and of established and to be identified biomarkers in blood and urine for clinical course and clinical and microbiological outcome of patients with a complicated urinary tract infection, treated in…

Implementation of a clinical decision rule to optimize hospital admission policy of patients with febrile urinary tract infection

To validate a clinical decision rule to guide need for hospitalization in patients presenting with febrile urinary tract infection (FUTI) with the aim to reduce the hospitalization rate without compromising clinical outcome.

Self-management as a first-line treatment prior to GP consultation for men with lower urinary tract symptoms

To assess the effectiveness and cost-effectiveness of providing an online personalized self-management program as a first-lineintervention to men with lower urinary tract symptoms (LUTS) compared to care as usual (CAU).

Long-term complications resulting from temporary indwelling urinary catheters in boys. A pilot study.

The aim of this study is to evaluate the: 1) prevalence of structural (urethral strictures) and 2) functional urethral complications (LUTS, abnormal uroflow characteristics and increased post void residual (PVR) volume) in boys post IUC placement.

*The Experience Sampling Method (ESM):
a real-time Patient-Reported Outcome Measure for symptom assessment in patients with overactive bladder syndrome.*

This project will be subdivided into three sections:Part I. Comparison of the ESM vs. SR-BDs and other retrospective questionnaires in the assessment of urological complaints in OAB such as urgency. Part II. Validation of new patient-reported…

Urinary tract infections in postmenopausal women revisited

The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…

Antibiotic prescribing and Non-prescribing in Nursing home residents with signs and symptoms Ascribed to urinary tract infection

To evaluate whether actively drawing physicians attention to the revised UTI guideline results in more appropriate AB prescribing for NH residents with suspected UTI. This will be achieved in two ways: 1) to incorporate the algorithm of the revised…

Removal of indwelling urinary catheter after vaginal prolapse surgery; removal on first night versus first morning after surgery.

Primary objective: Does removal of an IUC late at night on the day of vaginal prolapse surgery lead to a decrease in clinical UTIs in the first six weeks after surgery compared to removal on the morning of the first day after surgery?Secondary…