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*The Experience Sampling Method (ESM):
a real-time Patient-Reported Outcome Measure for symptom assessment in patients with overactive bladder syndrome.*

This project will be subdivided into three sections:Part I. Comparison of the ESM vs. SR-BDs and other retrospective questionnaires in the assessment of urological complaints in OAB such as urgency. Part II. Validation of new patient-reported…

Faecal microbiota transfusion for decolonization of multidrug resistant Enterobacteriaceae in renal transplant recipients (RESET): a pilot study.

Primary Objective: To assess the efficacy and safety of faecal microbiota transfusion in female renal transplant recipients with intestinal carriage of extended-spectrum β-lactamase Enterobacteriaceae (ESBL-E) and/or carbapenemase producing…

The effect of methenamine hippurate to reduce antibiotic prescribing due to new episodes of urinary tract infections (UTI) in elderly women with recurrent UTI- a triple-blinded, randomized placebo-controlled phase IV study

Primary objective: The primary objective of this study is to investigate if taking methenamine hippurate reduce the need for antibiotic usage due to recurrent UTI (measured as the number of courses of antibiotics).Secondary objectives:to investigate…

Clinical investigation to evaluate the performance and safety of Ambu® aScope* 4 Cysto and aView* Urologia for flexible cystoscopy.

Evaluate the performance of Ambu® aScope* 4 Cysto and aView* Urologia for direct visualization and treatment of the urethra and bladder.Evaluate the patient tolerance to the procedure and the procedural time of Ambu® aScope* 4 Cysto and aView*…

Lower urinary tract symptoms in Parkinson's disease effectiveness of pelvic floor muscle exercises and electrical stimulation

Objective: To study the effectiveness of pelvic physical therapy and ES in patients with PD suffering from LUTS. Which are the most effective parameters for ES. Intervention: Intervention: 8 treatment sessions of 30 minutes pelvic physical therapy…

Urinary tract infections in postmenopausal women revisited

The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…

Gag Therapy for Recurrent urine tract infection Assessing Comparability to International Nitrofurantoin Gold standard study.

The main objective of the study is to compare efficacy between GAG therapy and gold standard treatment (AB prophylaxis) in the prevention of rUTI. Primary questionIs GAG therapy as efficacy as antibiotic prophylaxis in the prevention of rUTI?…

An explorative, single-center, feasibility study to collect data for the continuous development of the TENA Bladder Sensor Algorithm in adults during urodynamics.

Primary objectiveTo collect data for the continuous development of an algorithm to determine the bladder filling status with the future TENA Bladder Sensor.Secondary objectiveTo document adverse events (AE) and device deficiencies (DD): namely AEs,…

Double-blind, placebo-controlled phase 1 trial of nizaracianine administered in three divided doses to healthy volunteers

Primary• To assess the safety and tolerability in healthy volunteers of nizaracianine administered IV in three divided dosesSecondary• To perform pharmacokinetic analyses of blood and urine• To determine if bolus injection of nizaracianine enables…

Safety and tolerability of controlled Human Urine Transfusion for Urinary tract infection Prevention (SHUTUP): a pilot study

To investigate the safety and tolerability of controlled human urine transfusion in female patients with recurrent UTI*s.

Antibiotic prescribing and Non-prescribing in Nursing home residents with signs and symptoms Ascribed to urinary tract infection

To evaluate whether actively drawing physicians attention to the revised UTI guideline results in more appropriate AB prescribing for NH residents with suspected UTI. This will be achieved in two ways: 1) to incorporate the algorithm of the revised…

REPLACE: The impact of catheter replacement in patients with catheter-associated urinary tract infection

The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.

Pharmacokinetics of fosfomycin: a study in patients with prolonged treatment for urinary tract infection

The aim of this study is to evaluate and describe the PK of fosfomycin in individuals receiving oral treatment with multiple dosages of fosfomycin for recurrent and/or complicatedurinary tract infection. The results of this study will be used to…

A Randomized, Placebo-Controlled, Phase-2A, Pilot Study to Evaluate the Effects of a Multi-Species Probiotic Formulation on the Quality of Life of Female Recurrent Urinary Tract Infection Patients

Primary Objective: 1. To assess the impact of Winclove CLEAR on the quality of life of female rUTI patients.Secondary Objectives: 2. To assess the impact of Winclove CLEAR on the incidence of UTI and the (associated) urinary microbiota composition…

DUET-trial; DoUble j or External stenting during kidney Transplantation? Study-protocol

Therefore, in the DUET-trial we will investigate whether double J stenting is indeed superior to the use of an external stent in reducing the number of urological complications after kidney transplantation, as measured by the number of PCN…

A PHASE III, MULTICENTRE, RANDOMISED, DOUBLE BLIND, PARALLEL GROUP,
PLACEBO CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF
ONE OR MORE INTRADETRUSOR TREATMENTS OF 600 OR 800 UNITS OF
DYSPORT® FOR THE TREATMENT OF URINARY INCONTINENCE IN SUBJECTS
WITH NEUROGENIC DETRUSOR OVERACTIVITY DUE TO SPINAL CORD INJURY
OR MULTIPLE SCLEROSIS

Target Population:Subjects with urinary incontinence (UI) caused by neurogenic detrusor overactivity (NDO)due to either spinal cord injury (SCI) or multiple sclerosis (MS), who have not beenadequately managed with oral medication and who routinely…

Removal of indwelling urinary catheter after vaginal prolapse surgery; removal on first night versus first morning after surgery.

Primary objective: Does removal of an IUC late at night on the day of vaginal prolapse surgery lead to a decrease in clinical UTIs in the first six weeks after surgery compared to removal on the morning of the first day after surgery?Secondary…

E-health in incontinence: from U-Pad to I-Pad

This trial aims to study the effects, costs and cost-effectiveness of an App-based program for women 18 years or older withurinary incontinence (UI) in primary care compared to care delivered by the general practitioner (GP) according to the…

The effect of direct urinary catheter replacement among adults with UTI, systemic manifestations and indwelling catheter in comparison with replacement after two days of antibiotics.

The purpose of this pilot study is to determine the optimal timing to replace a catheter in patients with an indwelling catheter and systematic symptoms of an UTI.

RUTI-FREEDOM: Recurrent Urinary Tract Infections in Females Receiving Effective Education, Digital Outreach & Management - a multicenter prospective randomized controlled trial in the Netherlands

A pilot study on digital coaching in rUTI at the Urology Department of Isala tested an app-based treatment additional to standard care.[8] The app provides information on rUTI aetiology, lifestyle recommendations, treatments, and the value of…