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Determination whether the lack of functional AQP2 in kidneys of patients suffering from nephrogenic diabetes insipidus induces cyst formation

Does the lack of the Aquaporin-2 water channel cause cyst formation in patients suffering from nephrogenic diabetes insipidus?

Single Blind Randomized Phase III Trial to Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer

- Primary study objective: To demonstrate the superiority of the ablative microboost dose schedule regarding 5-year biochemical no evidence of disease rate compared to the current standard of care.- Secondary study objectives: Establish and compare…

LUTS-BPH in general practice, a new approach

Primary Objective: To answer the following question: Does the extended approach (defined as uroflowmetry and bladder scan after the first consultation, followed by a check-up in month 3 of the male patient over 50 years of age first presenting with…

TRanslabial 3D-Ultrasonography for DIagnosing Levator defects

Objective:Primary aim of the study is estimating the diagnostic accuracy of translabial 3D ultrasonography of thepelvic floor as compared to MR imaging, the reference standard, for diagnosing levator defects inwomen with POP. Our secondary aim is…

Intracytoplasmatic Sperm Injection using testicular spermatozoa in men with azoospermia; an observational study with follow-up of the offspring.

To evaluate the efficacy of TESE and to describe the risks of the TESE procedure for the men with a four year follow-up of their offspring.

Application of PET-MR- a diagnostic accuracy study of combined dwMRI and 18F-Choline PET-CT for baseline staging of prostate cancer validated by extended laparoscopic lymph node dissection.

To compare the diagnostic performance of new lymph node staging methods for prostate cancer (dwMRI fused with 18F-Choline PET-CT) with the current gold standard of staging, the extended pelvic lymph node dissection (ELND)

Validation and standardization of the measurement of pelvic floor dysfunction with the MAPLE-probe

A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…

A randomised controlled trail comparing the TVT-O® with the Ajust® as primary surgical treatment of female stress urinary incontinence.

Objective: Primary Objective: to compare the immediate and postoperative pain (up to 6 weeks) between the Ajust® and TVT-O® proceduresSecondary Objective(s): 1. Objective cure of the SUI at 6 and 12 months follow up2. Subjective cure and improvement…

153Sm-EDTMP versus docetaxel for multiple painful osseous metastases in prostate cancer

The sequential application of chemotherapy and radionuclide treatment in patients with symptomatic osseous metastasized prostate cancer. Patients with more than one painful osseous metastasis will be randomized between 153Sm-EDTMP or docetaxel 3…

Clinical and histologic effect of transrectal intraprostatic injections with botulinum toxin in patients with lower urinary tract symptoms caused by benign prostatic hyperplasia.

To determine the effect on lower urinary tract symptoms and to determine urodynamic and histologic changes after intraprostatic botulinum toxin type A injection.

Pelvic organ prolapse in general practice: effects of pelvic floor physiotherapy and of pessary treatment

The objective of the project is to study the effect of conservative, non-surgical treatments of pelvic organ prolapse in a randomized clinical trial. The treatments under study, pessaries and pelvic floor physiotherapy, aim at reducing the symptoms…

Evaluation of the pelvic floor patients with Pelvic Organ Prolaps (POP) and controls, using dynamic MRI and Diffusion Tensor Imaging (DTI).

In this study we aim to evaluate pelvic floor structures in both POP patients and controls with the use of different anatomical landmarks and reference lines in non-invasive dynamic MRI. Additionally we propose to evaluate the feasibility of DTI in…

A Phase III, Randomised, Double-blind Study to Assess the Efficacy and Safety of 10 mg ZD4054 versus Placebo in Patients with Hormone-resistant Prostate Cancer and Bone Metastasis who are Pain Free or Mildly Symptomatic

To Assess the Efficacy and Safety of 10 mg ZD4054 versus Placebo in Patients with Hormone-resistant Prostate Cancer and Bone Metastasis who are Pain Free or Mildly Symptomatic

Pilotstudy to characterise prostate tissue using dynamic contrast enhanced (DCE-) MRI in patients with localised prostate cancer.

This is a pilotstudy after characterising prostate tissue by using DCE-MRI in patients with a localised prostate cancer.The relation between DCE-MRI and vasculature and oxygenation will be investigated as a preparation for further studies.

The multiparameter MLC-CFSE test to predict T cell-allo-immune reactivity in renal transplant recipients.

To select T cell properties intrinsic to the transplant recipient, which can discriminate between patients who will likely experience acute cellular rejection episodes from those who don*t.

A Phase III, Randomised, Placebo-controlled, Double-blind Study to Assess the Efficacy and Safety of Once-daily Orally Administered ZD4054 10 mg in Non-metastatic Hormone-resistant Prostate Cancer Patients

To Assess the Efficacy and Safety of Once-daily Orally Administered ZD4054 10 mg in Non-metastatic Hormone-resistant Prostate Cancer Patients compared to placebo.

A randomized clinical trial of urinary incontinence in older women: cost-effectiveness of protocolized assessment and evidence-based treatment

The study aims at delivering effective care for older women with urinary incontinence. This condition is underdiagnosed and undertreated, though effective treatments are available to manage urinary incontinence. Therefore, it is important to study…

Pilot study for the project:
A randomized clinical trial of urinary incontinence in older women: cost-effectiveness of protocolized assessment and evidence based treatment

The objective of the pilot study is to get information on the recruitment of patients, the filling in of the questionnaires, the micturition diary, the course of and information from the interview and about the logistics of the urogynaecological…

StoMakker: Improving the quality of life of children receiving an ileostomy, colostomy or continent urostomy by offering access to a peer support platform, age dependent information provision and games in a smartphone application

The main objective of this study is to investigate whether access to a peer support platform, age-dependent information provision and games in a smartphone application increases self-reported quality of life, for children receiving a stoma.

The external validation of a prediction model for anatomical cystocele recurrence after primary anterior colporrhaphy

The primary objective of this research is external validation of the prediction model that preoperatively estimates the risk of anatomical cystocele recurrence after primary anterior colporrhaphy. The secondary objectives are to identify risk…