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Single Blind Randomized Phase III Trial to Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer

- Primary study objective: To demonstrate the superiority of the ablative microboost dose schedule regarding 5-year biochemical no evidence of disease rate compared to the current standard of care.- Secondary study objectives: Establish and compare…

Outcome study on gender identity, sexual functioning and psychological well being in patients with a disorder of sexual differentiation

In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well

The effect of position (sit/stand up vs supine position) on urge sensation in volunteers and in patients with overactive bladder syndrome

The primary objective of this experiment is to describe via an observational study the relation between conditions of sitting/standing up versus laying down in terms of bladder sensation in both volunteers and patients with OAB. We also want to…

T cell homeostasis after ATG induced lymphocytopenia in renal transplant patients; studied through in vivo 2H2O labeling

To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.

Intracytoplasmatic Sperm Injection using testicular spermatozoa in men with azoospermia; an observational study with follow-up of the offspring.

To evaluate the efficacy of TESE and to describe the risks of the TESE procedure for the men with a four year follow-up of their offspring.

Validation and standardization of the measurement of pelvic floor dysfunction with the MAPLE-probe

A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…

Long term functional outcome, quality of life, and genetic factors in patients with a cloacal malformation

The primary objective to our study is assessing functional outcome, quality of life, and genetic mutations in patients with a cloacal malformation. Functional outcome:- Colorectal functiono Objective: assessing colorectal function through the use of…

THE KIMONO-study - on the development of renal injury in children with a solitary functioning kidney.

THE KIMONO-STUDY is designed to study the consequences of having an SFK from childhood. Furthermore, a tailor made risk profil will be designed for children with an SFK, based on individual risk factor (for example co-morbidity, genetic aberrations…

A randomised controlled trail comparing the TVT-O® with the Ajust® as primary surgical treatment of female stress urinary incontinence.

Objective: Primary Objective: to compare the immediate and postoperative pain (up to 6 weeks) between the Ajust® and TVT-O® proceduresSecondary Objective(s): 1. Objective cure of the SUI at 6 and 12 months follow up2. Subjective cure and improvement…

153Sm-EDTMP versus docetaxel for multiple painful osseous metastases in prostate cancer

The sequential application of chemotherapy and radionuclide treatment in patients with symptomatic osseous metastasized prostate cancer. Patients with more than one painful osseous metastasis will be randomized between 153Sm-EDTMP or docetaxel 3…

Clinical and histologic effect of transrectal intraprostatic injections with botulinum toxin in patients with lower urinary tract symptoms caused by benign prostatic hyperplasia.

To determine the effect on lower urinary tract symptoms and to determine urodynamic and histologic changes after intraprostatic botulinum toxin type A injection.

Pelvic organ prolapse in general practice: effects of pelvic floor physiotherapy and of pessary treatment

The objective of the project is to study the effect of conservative, non-surgical treatments of pelvic organ prolapse in a randomized clinical trial. The treatments under study, pessaries and pelvic floor physiotherapy, aim at reducing the symptoms…

A Phase III, Randomised, Double-blind Study to Assess the Efficacy and Safety of 10 mg ZD4054 versus Placebo in Patients with Hormone-resistant Prostate Cancer and Bone Metastasis who are Pain Free or Mildly Symptomatic

To Assess the Efficacy and Safety of 10 mg ZD4054 versus Placebo in Patients with Hormone-resistant Prostate Cancer and Bone Metastasis who are Pain Free or Mildly Symptomatic

A Phase III, Randomised, Placebo-controlled, Double-blind Study to Assess the Efficacy and Safety of Once-daily Orally Administered ZD4054 10 mg in Non-metastatic Hormone-resistant Prostate Cancer Patients

To Assess the Efficacy and Safety of Once-daily Orally Administered ZD4054 10 mg in Non-metastatic Hormone-resistant Prostate Cancer Patients compared to placebo.

StoMakker: Improving the quality of life of children receiving an ileostomy, colostomy or continent urostomy by offering access to a peer support platform, age dependent information provision and games in a smartphone application

The main objective of this study is to investigate whether access to a peer support platform, age-dependent information provision and games in a smartphone application increases self-reported quality of life, for children receiving a stoma.

A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus
Leuprolide, Enzalutamide Monotherapy, and Placebo Plus Leuprolide in Men
With High-Risk Nonmetastatic Prostate Cancer Progressing After Definitive
Therapy.

This study has been transitioned to CTIS with ID 2024-513521-23-00 check the CTIS register for the current data. All efficacy and safety objectives will compare enzalutamide plus leuprolide and enzalutamide monotherapyversus placebo plus leuprolide.

Neo-adjuvant versus Adjuvant chemotherapy in Upper Tract Urothelial Carcinoma: A feasibility phase II randomized clinical trial (*URANUS*)

This study has been transitioned to CTIS with ID 2024-514991-41-01 check the CTIS register for the current data. To assess the proportion of UTUC patients with adequate renal function and fit to receive either neo- or adjuvant cisplatin-based…

The *Utrecht Prostate Cohort for cancer treatment intervention studies and long term evaluation (UPC)* study

To set up a cohort that will serve as a multi-trial platform and facilitate evaluation of new interventional treatment for prostate cancer.

Cost-effectiveness of a Non-degradable Urethral Bulking Agent as compared to Mid-urethral Sling surgery in women with Stress Urinary Incontinence

We propose a study to compare the cost-effectiveness of the new UBA to MUS surgery.

Quality of life, cognitive function, and physical fitness of patients surviving more than 2 years after immune checkpoint inhibitor therapy

Primary Objective: - to investigate health-related quality of life (HRQoL) of patients surviving 2 years or more after the first cycle of an immune checkpoint inhibitor for melanoma or NSCLC.Secondary Objectives:- to assess neurocognitive function,…