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Economic evaluation of an e-mental health intervention for patients with retinal exudative diseases (E-PsEYE) who receive intra-ocular anti-VEGF injections: RCT

To evaluate whether the e-mental health intervention E-PsEYE is cost-effective in comparison with usual care from a healthcare and societal perspective in reducing depression and anxiety in patients with retinal exudative diseases. In addition, a…

A pilot study towards a therapy with prednisolone encapsulated liposomes for the treatment of Graves* Orbitopathy with reduced systemic steroid exposure

To demonstrate that Nanocort is safe and effectively reduces the inflammatory signs and symptoms of active GO.

The Vitreous Wipe. Clinical evaluation of an investigational medical device.

To establish the proportion of complete vitreoschisis removal with PVA.

A randomized, double blind (sponsor open), comparative, multicenter study to evaluate the safety and efficacy of subcutaneous belimumab (GSK1550188) and intravenous rituximab coadministration in subjects with primary Sjögren*s syndrome.

To evaluate the safety and efficacy of subcutaneousbelimumab (GSK1550188) and intravenous rituximab coadministrationin subjects with primary Sjögren*s syndrome.

A randomised clinical trial objectively comparing the effect of patching therapy with video gaming for amblyopia

To achieve a valid comparison of the effect of gaming and patching therapy on visual acuity, with compliance measured electronically.

A Randomized Study Comparing the Safety and Efficacy of the InnFocus MicroShunt® Glaucoma Drainage System to Standard Trabeculectomy In Subjects with Primary Open Angle Glaucoma

The study objective is to assess the safety and effectiveness of the InnFocus MicroShunt when used to lower intraocular pressure (IOP) in subjects with primary open angle glaucoma where the IOP is not controlled when using maximum tolerated glaucoma…

Comparing the effectiveness and costs of bevacizumab to ranibizumab in patients with retinal vein occlusions

The goal of the trial is to compare the efficacy and costs of bevacizumab 1.25 mg and ranibizumab 0.5mg given as monthly intravitreal injections over 6 months for the treatment of macular edema secondary to a retinal vein occlusion.

Safety and Efficacy with Twice Daily Brinzolamide 1% / Brimonidine 0.2% (SIMBRINZA) as an Adjunctive Therapy to Travoprost 0.004% / Timolol 0.5% (DUOTRAV)

To demonstrate the additive IOP lowering effect of SIMBRINZA (dosed BID) when added to DUOTRAV solution in subjects with open-angle glaucoma or ocular hypertension.

Multicenter, open-label study to assess the effects of Certolizumab Pegol on the reduction of anterior uveitis flares in axial spondyloarthritis subjects with a history of anterior uveitis (C-view)

Primary objective:The primary objective of the study will be to demonstrate the effect of CZP treatment on the reduction of AU flares in subjects with both active axSpA and a documented history of AU.Secondary objective:The secondary objectives of…

CATALYST: Cataract Surgery in Conjunction with Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients with Mild to Moderate Primary Open-Angle Glaucoma

To demonstrate the clinical efficacy and safety profile of canaloplasty utilizing the iTrackTM Advance canaloplasty device performed via an ab-interno surgical technique achieves:1. Enhanced IOP reduction at 12 months due to the techniques ability…