51 results
The main objective is to determine if bisphosphonate therapy with etidronate leads to stabilization or attenuation of ongoing calcification in the leg arteries as quantified by 18F-sodium fluoride(18F-NaF) PET-CT imaging in patients with PXE.…
Primary: to compare the treatment effect of ranibizumab PRN (visual acuity loss and/or SD-OCT disease activity guided retreatment) versus aflibercept bimonthly regimen on central retinal thickness stability as measured by mean fluctuations between…
Primary objective:To demonstrate that an individualized stabilization-criteria-driven PRN dosingregimen (PRN) with 0.5-mg ranibizumab administered with or without adjunctive lasertreatment has superior efficacy as compared to the current standard of…
Primary ObjectiveTo investigate whether half-dose PDT treatment leads to a higher percentage of chronic CSC patients with subretinal fluid on OCT achieving an absence of this subretinal fluid on OCT as compared to HSML treatment.Secondary…
Primary: To demonstrate that intravitreal injection of 0.5 mg ranibizumab administered based on individual patient needs has superior efficacy compared to sham treatment in adult patients with visual impairment due to VEGF-driven ME. Secondary: Best…
Primary objectives:- To investigate the long-term outcome after successful treatment (no subretinal fluid on OCT) in the PLACE trial.- To investigate whether a cross-over treatment of half-dose PDT to HSML in cCSC patients who either did not respond…
The objective of this study is to observe the anatomical and functional outcomes of ocriplasmin over a 6-month follow-up period.
The primary objective of this study is to further evaluate the safety and tolerability of pegaptanib sodium in subjects with DME.
To assess the safety, tolerability and the effects of treatment on ocular outcomes following a single intravitreal administration of ESBA1008 compared to Lucentis in patients with exudative AMD
Determine whether phenylephrine or norepinephrine has superior haemodynamical effects in ophtalmic surgery
To study the impact of laser photocoagulation on the parafoveal visual field in a previously untreated population of patients with DME.
To examine features of treatment response on optical coherence tomography in patients who were switched to aflibercept after non-response to previous intravitreal anti-VEGF treatment.
The documentation of safety and performance of silicone oil as temporary tamponade in retinal surgery.
The primary objective is to evaluate the efficacy of an individualized stabilization criteriadrivenPRN dosing regimen with 0.5 mg ranibizumab as assessed by the mean best-corrected visualacuity (BCVA) change at Month 12 compared to Baseline.
The purpose of this study is to evaluate if microplasmin is safe and effective when injected into the vitreous without performing a vitrectomy.
Primary objective* To evaluate ocular and non-ocular adverse events during the 24-months study period in patients treated with Lucentis (0.5 mg)Secondary objectives* To describe the ocular and non-ocular adverse events over a cumulative 36-months…
To compare visual outcome and foveal function after (initiation of) treatment between patients receiving an RPE-choroid graft and patients with anti-VEGF medication.
Primary objective: To evaluate whether patients with a prolactinoma have signs of altered vascular function and/or morphology in the retina or sublingual tissues in comparison to healthy controls. Secondary Objectives: 1. To evaluate whether there…
The primary objective of this study is to estimate the incidence of ocular adverse events in patients with CNV secondary to AMD who receive an individualized treatment with ranibizumab 0,3 mg.
Het objectives of the study are to demonstrate that combination therapy of Lucentis and Visudyne is not inferior in effectivity and safety to monotherapy with Lucentis and to investigate whether less Lucentis injections in combination therapy with…