29 results
To demonstrate that DMEK is superior to DSAEK with respect to VA.
Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…
To evaluate the safety and efficacy of abicipar (2 mg), compared to 0.5 mg ranibizumab in treatment-naïve patients with neovascular AMD.
To evaluate the role of the epithelium in the effect of CXL for treatment of progressive KC and to determine whether the epithelium should be removed or can be left intact during treatment.
Assess raytracing algorithms in determining the refractive properties of the eye. This method is also applied to cataract patients and, therefore, a secondary objective is to determine the effects of surgical incisions on ocular refractive…
The objective of this study is to evaluate the safety of the AcuFocusTM ACI 7000PDT corneal inlay implanted intra-stromally in emmetropic presbyopes and the effectiveness of the inlay for improvement of near vision.
The study objectives are:- to characterize the biotransformation pathways, the routes and rates of excretion, and total recovery of the 14C-labeled research medication and its radiolabeled metabolites- to characterize the pharmacokinetics (PK) of…
Of each new device it is unknown what the validity is and what the differences (advantages and disadvantages) are compared to the daily used devices.The aim of this study is to answer the question: What is the validity and are the objective benefits…
Primary: to evaluate the effectiveness of two treatment regimens by assessing the average stable maximum best-corrected (BCVA) change from Month 4 to Month 12 compared to Month 3. A treatment regimen will be considered a relevant treatment option if…
The main objective is to establish whether a relationship can be demonstrated between the amount of light scattered at the post-operative corneal interface on the one hand and visual acuity and contrast sensitivity on the other. In addition, changes…
Evaluation of pre-operative parameters in order to ascertain the need for a keratoplasty after cataract surgery has been performed in eyes with Fuchs* endothelial dystrophy.
Our research proposal has several aims: 1) We propose to use large-scale genetic studies to identify allelic variants that influence the development of AMD, which will enable the development of diagnostic and prognostic tools in the near future. 2)…
Primary objectiveTo assess the efficacy of intravitreally (ITV) administered VEGF Trap-Eye compared to ranibizumab (in a non-inferiority paradigm) in preventing moderate vision loss in subjects with all subtypes of neovascular AMD Secondary…
To investigate if there is an association with the R142W mutation in the RDS gene in a group of dry AMD patients from the North Limburg region
The aim of this study is to use different non-invasieve techniques to measure the spatial distribution of the macular pigment and its possibly relation with retinal structure and contrast sensitivity.
- Development of FCSPCO.- Determine if straylight is a reliable parameter for FCSPCO.
To demonstrate that FS laser aided keratoplasty for KC is superior to MALK.
Investigate clinical anomalies in the intraocular tissues, especially the accommodation system, in RDEB patients.
• In this pilot study, PS-OCT is used to image differences in fibrillary ocular structures associated with disease in patients with glaucoma, high myopia, exudative age-related macular degeneration with a suspicion of subretinal fibrosis and…
The goal of this study is to characterize the natural history of STGD1 patients with the appropriate genotype for AON therapy and to identify the best clinical outcomes to measure therapeutic efficacy in clinical trials following completion of this…