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Corneal Transplantation by DMEK - is it really better than DSAEK?

The objective of this trial is to assess the effects and costs of DMEK vs. DSAEK in order to determine whether the new technique is effective and cost-effective over the standard technique.

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-MASKED, SHAM-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF LAMPALIZUMAB ADMINISTERED INTRAVITREALLY TO PATIENTS WITH GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION

EFFICACY OBJECTIVESThe primary efficacy objective of this study is to evaluate the efficacy of intravitreal injections of 10 mg lampalizumab administered Q4W or Q6W in CFI profile biomarker positive and CFI profile biomarker-negative patients…

A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-MASKED, SHAM-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF LAMPALIZUMAB ADMINISTERED INTRAVITREALLY TO PATIENTS WITH GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION

EFFICACY OBJECTIVESThe primary efficacy objective of this study is to evaluate the efficacy of intravitreal injections of 10 mg lampalizumab administered Q4W or Q6W in CFI profile biomarker positive and CFI profile biomarker-negative patients…

A phase 2b randomized, double-masked, controlled trial to establish the safety and efficacy of intravitreous administration of Fovista® (Anti-PDGFBB pegylated aptamer) administered in combination with Avastin® compared to Avastin® monotherapy in subjects with subfoveal neovascular age-related macular degeneration.

The objective of this trial is to evaluate the safety and efficacy of the combination of Fovista® intravitreous administration with Avastin® compared to Avastin® monotherapy.

Clinical Investigation of Visual Function After Bilateral Implantation of Two Presbyopia-Correcting Trifocal IOLs.

Primary Objective:To demonstrate noninferiority of ACRYSOF IQ PanOptix presbyopia-correcting IOL Model TFNT00 to the AT LISA tri IOL Model 839MP in mean photopic binocular uncorrected intermediate (60 cm) visual acuity at Visit 4A.Secondary…

Global Multicenter Study with the Hydrophobic Acrylic (HF) Iris-Fixated PIOL for the Correction of Myopia in Phakic Eyes

The purpose of the study is to investigate the safety and effectiveness of the HF IF PIOL, and to compare performance with the Artiflex lens. Study outcomes will be used to obtain CE marking for the lens and for registration and marketing purposes.

A randomized, double-masked, placebo-controlled, efficacy and safety study of RV 001, an insulin-like growth factor-1 receptor (IGF-1R) antagonist antibody (fully human), administered every 3 weeks (q3W) by intravenous (iv) infusion in patients suffering from active thyroid eye disease (TED)

The primary objective is to investigate the efficacy, safety and tolerability of RV 001 (a fully human anti-IGF-1R antibody) administered q3W for 6 months, in comparison to placebo, in the treatment of patients suffering from active TED.Secondary…

VISUAL OUTCOMES AFTER BILATERAL SURGICAL CATARACT PHACOEMULSIFICATION: ACRYSOF® RESTOR IOL IMPLANTATION COMPARED TO MONOFOCAL IOL IMPLANTATION

The objectives of this study are to assess and compare at 6 months 1) the percentage of subjects achieving bilateral uncorrected distance visual acuity and bilateral uncorrected near visual acuity <= 0.1 logMar; 2) spectacle independence at…

Efficacy and cost-effectiveness of toric intraocular lenses in correcting astigmatism in cataract surgery: A Randomised Clinical Trial

The primary objective of this study is to compare the quality of vision following toric IOL implantation and monofocal IOL implantation. The secondary objectives are to compare uncorrected distance vision, spectacle dependence, residual refractive…

Pilot study to compare straylight perception in pseudophakic subjects with different intraocular lenses

The purpose of this pilot study is to compare the perception of straylight in patients with CE marked multifocal intraocular lenses, measured with 4 different straylight measuring devices..

Prevalence of amblyopia, strabismus and refractive errors amongst children of the 7th grade and influence of spectacle correction of hypermetropia on reading ability

Main objectives: 1. to investigate the prevalence of vision abnormalities in 9- and 10 year old children; 2. to investigate the percentage of these vision abnormalities that were detected the VOV screening programme;3. to investigate whether these…

Corneal transplantation by ultra-thin DSAEK: thinner grafts, better vision?

The objective of this project is to assess the effects and costs of ultra-thin DSAEK vs. standard DSAEK in order to determine whether the new technique is effective and cost-effective over the standard technique.

CLINICAL OUTCOMES AFTER IMPLANTATION OF THE ACRYSOF® IQ RESTOR® +2.5 D MULTIFOCAL INTRAOCULAR LENS (MIOL) IN THE DOMINANT EYE AND RANDOMIZATION OF THE ACRYSOF® IQ RESTOR® +2.5 D OR +3.0 D MIOL IN THE FELLOW EYE

The primary objective is to demonstrate non-inferiority of patients bilaterally implanted with the AcrySof® IQ ReSTOR® +2.5 D MIOL to AcrySof® IQ ReSTOR® +2.5 D MIOL in the dominant eye and AcrySof® IQ ReSTOR® +3.0 D in the fellow eye in binocular…

A randomized, subject-blinded evaluation of visual function after bilateral implantation of two types of presbyopia-correcting multifocal IOLs

The objective of this study is to prospectively evaluate postoperative visual outcomes in a series of patients bilaterally implanted with the FineVision Micro F IOL versus those bilaterally implanted with the AcrySof® IQ ReSTOR® Aspheric +3 D…

A double blind randomized study on the efficacy of cyclopentolate 1% and cyclopentolate 1% with tropicamide 1% in children

To compare one dose of the short acting tropicamide combined with one dose of the longer acting cyclopentolate (c+t) with a double dose of the longer acting cyclopentolate (c+c). To develop a cycloplegics protocol that garantees optimal refractieve…

A Randomized, pilot study, subject-masked comparison of visual function after bilateral implantation of Presbyopia-correcting IOLs

The objective of this study is to prospectively evaluate postoperative visual outcome in a series of patients bilaterally implanted with the AcrySof® IQ ReSTOR® Aspheric +3 D multifocal IOL versus those bilaterally implanted with the LENTIS® Mplus…

Effect of improved intraocular lenses on contrast sensitivity tests

The aim of this study is to measure the results of refractive surgery with aspherical intra-ocular lenses quickly and reliably.

Counselling, prescription and instruction-effects of closed circuit television systems in rehabilitation of visually impaired adults.

The most important objectives in this study are: (1) the development of a standardized method to instruct and train patients how to use a CCTV; (2) the effectiveness of this instruction and training program in the use of a CCTV and (3) the…

The impact of orientation and mobility training on mobility, participation and quality of life in older adults with visual impairments: a randomized controlled trial

In light of the aforementioned the current study has three objectives:1) to standardize orientation and mobility instruction for older people with visual impairments who use the identification cane; 2) to evaluate the effects of this standardized…

A double blind randomized study on the effectiveness of cyclopentolate 1% and cyclopentolate 1% with tropicamide 1% in dark irided hypermetropic children

To compare the effectiveness of 1) double dose of cyclopentolate and 2) one dose of cyclopentolate and one dose of tropicamide with 3 days, total 5 doses atropine.To investigate whether one dose of tropicamide combined with cyclopentolate is as…