557 results
The primary objective is determining whether there is a difference in faecal microbiome constitutions in individuals with Asperger syndrome compared to their non-affected sibs. The secondary objectives are whether there is a correlation between…
The objective of the current study is to assess feasibility and acceptance of the pre-treatment assessments (PRoSPECTs feasibility study).
Primary Objective: - To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors.Secondary Objective(s): - To identify specific patterns of brain…
1) Establish a comprehensive clinical and antibody profile of autoimmune synaptic encephalitis in dementia syndromes. 2) To assess outcome and provide diagnostic guidelines who to test and in whom testing will be unnecessary, and elucidate…
Primary Objective: To identify reproducible neuroimaging signatures of OCDSecondary Objective: To link these neuroimaging signatures to specific cognitive functions and clinical profilesExploratory Aims: 1) To study how environmental factors may…
1. To identify biomarkers and methodologies (neuroimaging, eye tracking, cognition, biochemistry, proteomics, genomics, etc.) that can be used to stratify patient groups into more homogeneous subgroups and/or that predict clinical outcome of…
To explore regions of brain and brainstem activation in healthy volunteers during abdominal pain or discomfort after chemical nociceptive stimulation of the duodenum with capsaicin. In the future, we aim to perform the same study in IBS-/FD-patients…
The primary objective is the extent and kind of cognitive deficits in patients suffering from bipolar disorders compared to healthy controls and patients with a lifetime diagnosis of unipolar depressive disorder. Secondary objectives specify the…
The main objective of this study is to predict the rate of decline for both motor and cognitive function in an existing PD patient cohort using a combination of baseline CSF and blood biomarker profiles (T0). The secondary objective is to determine…
Discontinuation of ANtihypertensive Treatment in Older people with dementia living in a Nursing home
To assess whether discontinuation of antihypertensive treatment in nursing home residents with dementia a) reduces NPS and improves quality of life; b) improves general daily functioning and cognitive functioning; c) reduces psychotropic medication…
The primary objective is to investigate brain functioning during fear conditioning and reward/punishment conditions in relation to persistent and desistent DBD patterns by means of functional magnetic resonance imaging (fMRI), in a large cohort of…
We aim to assess the association between (cardio-)vascular and hemodynamic factors in relation to cognitive function.
Objective: The primary objective of this study is to investigate interoceptive abilities in adolescents with AN. To capture the multidimensional perspective, interoceptive abilities will be studied on an accuracy, sensibility and awareness level.…
Our primary objectives are to decode **signatures** of activity from the electrode that might prelude or accompany an OCD attack, by analyzing its activity in an experimental setting and in real-life situations, and to correlate symptom changes with…
The overall objective of this exploratory study is to develop a quantitative biological approach to the understanding and classification of the endophenotypes that contribute to neuropsychiatric diseases, to accelerate the discovery and development…
(1) To investigate the relationship between estradiol level and ADHD and mood symptoms within the menstrual cycle in women with ADHD. (2) To investigate if this relationship is comparable between women with and without ADHD.
We will study the cerebral glucose metabolism before, during and after surgery by sampling the cerebrospinal fluid (CSF) via the spinal catheter in patients undergoing thoracic surgery. Changes in cerebral glucose metabolism and activation of the…
The objectives of this study are threefold. First, we aim to understand the underlying neural mechanisms of suicidality. Therefore, we will investigate brain activation during resting state and three psychological processes that have been suggested…
We hypothesize that improving sleep will improve glycaemic control in people with T2DM and insomnia. To test this hypothesis, we established the following objectives: 1) investigate if improving sleep by internet-based cognitive behavioural therapy…
The main objective of this study is to identify prognostic, stratification, and/or outcome biomarkers for ASD. Prognostic marker refers to any objectively measurable test that helps to predict a child's likely developmental course; whether his…