557 results
Objectives: 1) Assess neural and cognitive biomarkers (through eye-tracking, EEG/ERP and cognitive measures) in a community sample of infants at heightened non-familial risk for ASD and in age and gender matched low-risk controls. The HR group is…
The primary objective of the MANTA-study is to investigate MEG-based network topology and 'activity dependent degeneration' as mechanisms in the stereotypical spread of tau pathology (18F-AV1451 retention) in preclinical and clinical…
To provide an answer to the following questions: 1. In patients with AD, does treatment with a ChEI improve cerebral hemodynamics? 2. Is there less progression of cerebrovascular lesions on follow-up of AD patients receiving ChEI*s? 3. Does this…
Main goal is to gain more insight in the role of dopaminergic neurotransmission in rewards, motivation and the attribution of salience in the etiology of psychosis. Primary question is whether a change in blood oxygation level dependent (BOLD) fMRI…
A longitudinal cohort of 550-600 children will be set up (10-25 years old, 450 children with and 100-150 children without a parent with mood disorders) on basis of already identified participants (parents) that are part of the NESDA, BiG, OPPER,…
To study the differences in MI between short-term ill adolescents with AN (< illness duration 1 year) and patients who started their illness in adolescence and have been ill for at least 5 years consecutively and with healthy controls. A…
1) To compare between treatment responders, treatment non-responders, and healthy controls: sDSC and GABA in the ACC;2) To assess, in psychotic patients and healthy controls, whether AEA and 2-AG plasma levels are associated with sDSC, and…
To provide an extensive clinical and psychosocial characterization of IBS patients with and without psychological and/or physical comorbidities, as well as of disease-controls without IBS, but with psychological and/or physical disease, and a…
The primary objective of this study is to determine if the binding of [11C]PK11195, as a measure of neuroinflammation, in schizophrenic patients is decreased after simvastatin treatment.
To investigate the role of the dopaminergic system in reward discounting and reward anticipation in ADHD and comorbid disorders. The study investigates the following question: Do patients with ADHD without comorbidity differ from those with ADHD and…
1) Identify potential mechanism(s) underlying the impact of an FFD on ADHD symptoms;2) Identify biomarkers that predict the response to the FFD.
The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…
Primary objectives- To investigate CSF autoantibodies (NMDAR, AMPAR, VGKC, and GABA receptors) in patients with a psychotic disorder and healthy controls. - To compare levels of immune parameters between patients with a psychotic disorder and…
The aim of this study is to investigate how many patients with an early and/or chronic psychotic disorder reach personal recovery during follow-up and which determinants and processes influence personal, clinical, functional and societal recovery…
Objectives: Primary objective: - To investigate whether high-resolution glutamate levels in the brain of patients that experienced a psychosis differ from healthy individuals.Secondary objectives:- To compare the high resolution glutamate…
The main objective of this study is whether EMDR is an appropriate treatment for women with PTSD after a previous birth. The resulting hypotheses are that at the two follow-up meaurements, in relation to the pretreatment-measurement 1) WITHIN the…
The aim of the current study is to investigate obsessive-compulsive symptoms and executive functioning in ED, BDD, OCD and ASD. Symptoms of ED, BDD, OCD and ASD will be assessed in all four disorders, as well as executive functioning. We hypothesize…
To conduct a pilot study on the relationship between measured sensitivity to reward and the effectiveness of a routine cognitive-behavioral intervention in ADHD. To pilot relevant measurements and generate hypotheses for a larger study in the future…
The primary objective is to investigate if there is a difference in the performance on tasks measuring visual perception and attention between visual hallucinating schizophrenic patients, schizophrenic patients who do not hallucinate and healthy…
The purpose of this study is to study the acquisition and extinction/counterconditioning of aversively conditioned sexual responses. The study will investigate how sexual stimuli may lose sexually rewarding properties by repeated pairing with…