557 results
To investigate the feasibility of fine-grained ambulatory cortisol signaling (total 72 hours, 20 minute intervals) in individuals with depression, PTSD and healthy controls in daily life. We will investigate whether the mean peak and trough values,…
The iBerry Study has two main study objectives:1. Descibing long-term prognosis of subclinical symptoms in terms of course (transition to several psychiatric disorders, chronicity, recurrence, comorbidiy) and public health consequences (disability,…
1. Provide post-trial access to bumetanide treatment for NDD participants.2. To test how bumetanide cohort data compare to the existing RCT data in terms of treatment effectiveness by using randomization tests. 3. To further develop EEG biomarker…
Identification of MRI-based biomarkers to predict clinical outcome of major depressive disorder in comparison with healthy controls. Outcome is defined by level of depressive and cognitive symptomatology and related comorbidity.
What are the differences and similarities of dopamine synthesis capacity between patients with AVH and BPD, those with schizophrenia, and healthy controls?
The objective of this study is to investigate body image disturbances in adolescents with anorexia nervosa. To capture the multidimensional perspective, body image disturbances will be studied on a perceptual, cognitive-affective and a behavioural…
In this project, we will combine cohorts from several countries into a comprehensive retrospective discovery cohort to examine theabove-mentioned markers focusing on sporadic cases and PPD, in addition to a large number ofpathologically confirmed…
- To assess platelet (dys)function in adults with 22q11.2DS and its association with bleeding history.- To identify alterations in metabolic pathways in 22q11.2DS that may be of relevance to mechanisms underlying neurodevelopmental and…
The objective of the study is to determine the difference in brain responses after consumption of processed and unprocessed food between healthy lean subjects with a *normal* eating pattern with that of Binge Eating Disorder (BED) patients, who are…
The main objective is to assess long-term neurodevelopmental, cardiovascular, pulmonary, and growth outcomes in a cohort of MC twins with sFGR and to compare outcomes within sFGR twin pairs.
* To examine the effects and interactions of individual and environmental factors on the onset and course of mental health problems in adolescents and young adults. * To examine the effects and interactions of individual and environmental factors on…
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal, neurocognitive and cardiovascular health (dependent variables) of professional…
Project aims1. To provide a more precise overview of prevalence, presenting symptoms, referral routes, clinical complications and evolution during follow-up of PIDs in The Netherlands by registration and analysis of prospective patient data derived…
The primary objective of the study is to explore whether immune activation potentiates stress vulnerability by increasing serotonin dysfunction (lower tryptophan ratio*s). This objective is based on the hypotheses that pro-inflammatory cytokines…
To determine whether reactive gliosis persists >3 years after SAH and whether this response relates to cognitive impairment after SAH.
The aim of this study is to gain knowledge about how disgust may contribute to the eating disorder Anorexia Nervosa (AN). Part 1 aims to test a theoretical model on the relationship between disgust propensity, disgust sensitivity, self-disgust and…
The iBerry Study has two main study objectives:1. Describing long-term prognosis of sub-threshold symptoms in terms of course (transition to several psychiatric disorders, chronicity, recurrence, co-morbidity) and public health consequences (…
The purpose of the study is to identify genes and genetic mechanisms that contribute to TD, chronic tics, and related clinical disorders including OCD and ADHD in individuals with these clinical phenotypes and their relatives.
The general aim of this project is to better understand the mechanisms involved in safety learning, specifically in adolescents with and without clinical anxiety. First, we aim to investigate differences in vicarious and non-vicarious safety…
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…