267 results
Our primary objectives are to study in patients with OCD 1.) Whether stress facilitates a shift from goal-directed to habitual behaviour (both appetitive and avoidant); 2.) Whether stress facilitates compulsive behavior through an enhancement of…
Objective: Primarily, the objective of this study is to assess the role of serotonergic and dopaminergic polymorphisms in fear conditioning. Secondary, we will investigate additional cannabinergic and corticotropinergic polymorphisms in fear-…
This study addresses the following three questions:1. How do fear memories change over time?2. How is the context of fear coded in the brain?3. How can the process of excessive strengthening of fear memory be disrupted
Primary Objective: Using fMRI to assess differences in brain activation during: (a) up- and down-regulation of emotional reaction to negative and positive pictures vs neutral pictures; and (b) working memory at low and high load with emotional…
Primary Objective is to determine whether (A) patients with dystonia(plus) syndromes exhibit more psychiatric symptoms compared to a healthy control group and (B) whether dystonia patients show an altered serotonin metabolism (serotonin transporter…
Aims:a) Understand persistence and/or plasticity of the brain correlatesb) Understand specificity of the brain correlatesQuestions:a) Which neural correlates of OCD are state dependent and thus normalized after successful treatment?b) Which neural…
If normal doubt occurs, will OCD patients differ from non-OCD anxiety patients and healthy controls in how much uncertainty they will experience and will OCD patients respond to this with more perseveration (chekcing behavior) than non-OCD anxiety…
The main objective of this pilot study is twofold: 1) To investigate whether and to what extent raped adolescents experience symptoms of posttraumatic stress disorder at maximum 18 months of follow-up, measured by standardised questionnaires and…
To extend our understanding of brain mechanisms involved in intrusive memory degrading by eye movement during recall of traumatic memories in the treatment of PTSD.Brain areas involved in visual imagery are well-documented, and comprise the primary…
The main objective for this proposal is to investigate the neurophysiology of BDD, and compare irregularities of BDD neurophysiology with OCD neurophysiology.
To assess the long-term consequences of live kidney donation, regarding kidney function, survival, hypertension, diabetes, systolic and diastolic blood pressure, mental state and quality of life.
The overall aim of this study is to investigate interoceptive conditioning of fear and it*s generalization in both panic/anxiety patients and healthy control subjects. Therefore we have three specific objectives. The first objective is to replicate…
To test the effectiveness of the psychotherapy "Seeking Safety" in a Dutch SUD sample.
Objective: The primary aim of the present study is to investigate the effectiveness of MBCT in a group format versus TAU in a group format for treatment refractory anxiety disorders Furthermore; we will investigate mediators associated with…
Cognitive behavior therapy (CBT) seems a promising intervention to reduce FCR. The SWORD study (Survivors* Worries of Recurrent Disease) will examine the efficacy and cost-effectiveness of individual CBT compared to treatment as usual (TAU) in…
The objective for this study is to examine alpha suppression in PTSD and evaluate it as a predictor of treatment outcome. We will first examine if there are differences in alpha suppression PTSD patients (prior to treatment) and the typical…
RESEARCH QUESTIONS* Is the currently used RNAF protocol for the acute medical care on the Battlefield sufficient.* What recommendation can be made to enhance this protocol, with emphasis on the transfer of information from battle field to second…
The aim is to determine on the basis of the results of this study whether there is measurable effect on the ability to drive after long term use of ICADTS class III drugs. To achieve this goal drugs will be tested out of the groups most commonly…
Objective: The main objective is to evaluate the effectiveness of the POPP-treatment program in reduction of severity of post-traumatic stress symptoms for sexually abused preschoolers. Secondary objectives are to evaluate the effectiveness of the…
The first objective is to assess the effect of age and anxiety disorder on use and effectiveness of emotion regulation strategies in circumscribed vs. complex daily life situations. The second objective is to assess the effect of treatment of…