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Web-based attention bias modification treatment for childhood anxiety disorders: a randomized, double-blind, controlled trial

Specific AimsAs reviewed above, childhood anxiety disorders are highly prevalent and debilitating, and there is an urgent need for improvement of current treatment strategies. An innovative, but scarcely examined, treatment option for childhood…

Randomized controlled trial of escitalopram versus placebo for patients with irritable bowel syndrome and panic disorder.

PRIMARY OBJECTIVE· 1. To study the effect of escitalopram versus placebo in the treatment of abdominal pain, in IBS patients with panic disorder.SECONDARY OBJECTIVES· 2.1. To assess the effect of escitalopram on gastrointestinal and psychiatric…

Boosting Oxytocin after trauma: Neurobiology and the Development of Stress-related symptoms.

Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…

Cannabidiol enhancement of exposure therapy in treatment refractory patients with phobias.

The aim of this research project is to investigate cannabidiol as a new medicine to target the cannabinoid system in the reduction of anxiety disorder symptoms. The research question is whether cannabidiol, as an augmentation strategy of exposure…

Enhancement of exposure therapy for social anxiety disorder with testosterone: A randomized placebo controlled clinical trial

To investigate the efficacy of testosterone enhanced exposure therapy for social anxiety disorder.

A randomised comparison of Eye Movement Desensitization and Reprocessing (EMDR), Narrative Exposure Therapy (KIDNET) and waiting list control in traumatized refugee children.

The study aims to answer the following research questions:1. How high/low are levels of symptomatology of depression and/or PTSD in traumatised refugee children in ASC?2. Do symptom levels decrease after a short-term trauma-focused intervention?3.…

A Randomized, Placebocontrolled, Double blind, Single Ascending Dose Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-61393215 in Healthy Subjects

The primary objectives of this study in healthy subjects are:- To investigate the safety and tolerability of JNJ-61393215 versus placebo after single oral dose administration under fasted (ascending dose levels) and fed condition.- To characterize…

Acute effects of 40 mg cortisol on emotion and cognition.

To investigate acute effects of a single 40 mg dose hydrocortisone, compared with placebo, on stress and various aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy anxious young females. The main question…

Is clinical DBT-PE the revolution we have all been waiting for in the treatment of victims of childhood sexual abuse?

The current study aims to replicate the Bohus study published in 2013, comparing the effect of a 12-week residential DBT-PE program on the severity of PTSD to that of a waiting list condition in patients who suffer from CSA related PTSD and from one…

The STAP-study: Skills training and traumafocused treatment in multiple interpersonal traumatized adolescents with PTSD.

The randomized controlled trial (RCT) will be performed at Karakter Child and Adolescent*s Psychiatric Hospital and will be implemented at all locations, spread out over three provinces in The Netherlands. The project aims:1. To explore the…

The effects of propranolol on fear of tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

The aim of this study is to determine the effects of propranolol on patients* crucial fear-related memories and dental trait anxiety in those undergoing surgical removal of one of their teeth or molars. The hypotheses that are tested are that…

Self-Esteem Treatment in Anxiety - positive versus negative memory representations

We want to answer the following research questions:- Which of the mentioned treatment approaches is more effective for improving self-esteem?- Do both approaches have additive value (does a patient benefit more after receiving both treatments, in…

Automatization and defamiliarization in Obsessive Compulsive Disorder

Primary objective 1: Does repeated relevant checking in general lead to automatization in OCD patients? Primary objective 2: If automatization as a result of repeated relevant checking occurs, do OCD patients differ from other anxiety disorder…

Body awareness training in the trEatment of Wearing-off related Anxiety in patients with paRkinson*s diseasE.

The current proposal aims at investigating the effect of a multidisciplinary non-verbal intervention on the awareness and modulation of WRA to improve self-efficacy, mobility, mood, and quality of life as compared to usual care.

Towards a better trauma treatment for older adults:
From comparative research to actual implementation.

a. By this research a treatment protocol for NET will be quantitatively and qualitatively evaluated on its effects. b. With the research findings it is possible to identify subgroups within the research population and indicate who benefits most from…

Boosting oxytocin after trauma: The effects of intranasal oxytocin administration on emotional and motivational brain processes in PTSD

In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…

(Cost) effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in cancer patients: a superiority trial of online versus face-to-face treatment versus treatment as usual (TAU).

The current study aims at investigating whether individual mindfulness-based cogntiive therapy (MBCT) online and MBCT offered face-to-face in groups are superior to a waiting list-control group in terms of improvement of depression and anxiety,…

The effect of cognitive bias modification of interpretive bias in the treatment of dental phobia

Investigation of the effect of interpretive bias modification on anxiety levels in dental phobia. If CBM-I indeed has positive effects in the treatment of dental phobia, it could be integrated in the treatment-as-usual as an additional intervention…

A Study on the Efficacy of Virtual Reality Exposure Therapy (VRET) for Survivors of Childhood Sexual Abuse and War related Trauma

This study will examine the efficacy of this Virtual Reality Exposure Therapy (VRET) in a CSA and war related trauma sample by comparing it with treatment as usual (TAU). It will also attempt to develop protocols to implement this new technology…

Finding the optimal treatment of severe panic symptoms in patients presenting at the emergency department with non-cardiac chest pain or palpitations. A cognitive behavioural therapy based intervention versus an information sheet. A randomized controlled trial.

The objective of our study is to examine the effectiveness of a cognitive behavioural therapy based intervention compared to an information leaflet on anxiety symptoms after one month, in patients presenting at the emergency unit with non-cardiac…