108 results
Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…
zie NL
The main objective of the current project is to characterize hippocampal neural (dys)function in the process pattern separation by comparing subjects along their performance on a behavioural pattern separation task.
To investigate acute effects of a single 40 mg dose hydrocortisone, compared with placebo, on stress and various aspects of attention and other cognitive processing of emotionally relevant stimuli in healthy anxious young females. The main question…
In this proof-of-concept study, we aim to characterize healthy individuals with regard to their individually predominant neural mechanism. Thereby, we aim to divide a sample of healthy individuals into three clusters based on their individual…
The main objective of this study is to determine the role of freeze-fight-flight reactions in the development and maintenance of PTSD symptomatology.
Our primary objectives are to study in patients with OCD 1.) Whether stress facilitates a shift from goal-directed to habitual behaviour (both appetitive and avoidant); 2.) Whether stress facilitates compulsive behavior through an enhancement of…
Objective: Primarily, the objective of this study is to assess the role of serotonergic and dopaminergic polymorphisms in fear conditioning. Secondary, we will investigate additional cannabinergic and corticotropinergic polymorphisms in fear-…
This study addresses the following three questions:1. How do fear memories change over time?2. How is the context of fear coded in the brain?3. How can the process of excessive strengthening of fear memory be disrupted
Primary Objective: Using fMRI to assess differences in brain activation during: (a) up- and down-regulation of emotional reaction to negative and positive pictures vs neutral pictures; and (b) working memory at low and high load with emotional…
Primary Objective is to determine whether (A) patients with dystonia(plus) syndromes exhibit more psychiatric symptoms compared to a healthy control group and (B) whether dystonia patients show an altered serotonin metabolism (serotonin transporter…
Aims:a) Understand persistence and/or plasticity of the brain correlatesb) Understand specificity of the brain correlatesQuestions:a) Which neural correlates of OCD are state dependent and thus normalized after successful treatment?b) Which neural…
If normal doubt occurs, will OCD patients differ from non-OCD anxiety patients and healthy controls in how much uncertainty they will experience and will OCD patients respond to this with more perseveration (chekcing behavior) than non-OCD anxiety…
Primary objective 1: Does repeated relevant checking in general lead to automatization in OCD patients? Primary objective 2: If automatization as a result of repeated relevant checking occurs, do OCD patients differ from other anxiety disorder…
The main objective for this proposal is to investigate the neurophysiology of BDD, and compare irregularities of BDD neurophysiology with OCD neurophysiology.
The overall aim of this study is to investigate interoceptive conditioning of fear and it*s generalization in both panic/anxiety patients and healthy control subjects. Therefore we have three specific objectives. The first objective is to replicate…
The objective for this study is to examine alpha suppression in PTSD and evaluate it as a predictor of treatment outcome. We will first examine if there are differences in alpha suppression PTSD patients (prior to treatment) and the typical…
RESEARCH QUESTIONS* Is the currently used RNAF protocol for the acute medical care on the Battlefield sufficient.* What recommendation can be made to enhance this protocol, with emphasis on the transfer of information from battle field to second…
The first objective is to assess the effect of age and anxiety disorder on use and effectiveness of emotion regulation strategies in circumscribed vs. complex daily life situations. The second objective is to assess the effect of treatment of…
1. Examine the physiological, endocrinological and neural differences between children with PTSD and without PTSD2. Examine if neurobiological treatment effects of TF-CBT and EMDR differ and if so how3. Examine if neurobiological treatment effects…