35 results
Provide proof-of-concept for the hypothesis that guanfacine diminishes cognitive side-effects in ER+ BC patients treated with adjuvant hormonal therapy. Secondary, provide data for power calculations in later studies.
To investigate the efficacy of a less intensive but more prolonged Cogmed © RM WMT (including active personalized coaching and feedback) in reducing behavioral symptoms and improving neurocognitive functioning and academic achievements in children…
The objective of this experiment is to establish the effects of tyrosine suppletion on cognitive symptoms seen in ADHD. Cognition will be assessed, while simultaneously recording brain activity.
Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…
Primary objectives:To determine the exposure-response relationship of EVP-6124 over a range of plasma concentrations in a scopolamine-induced cognitive deficit model in healthy elderly subjects.Secundary objectives:To determine the exposure-response…
We aim to examine, in the impaired older population, whether a treatment using methylphenidate, a DA re-uptake inhibitor that enhances DA, improves attention and memory.
Primary :to evaluate the safety and tolerability of EVP-0962 after single and multiple ascending dose administrations in healthy subjectsSecondary :to determine the pharmacokinetic profile of single and multiple oral doses of EVP-0962 and to assess…
- to evaluate the safety and tolerability of a single oral dose of SCH 900229 administered to healthy adult volunteers- to characterize the pharmacokinetic (PK) profile of SCH 900229 in plasma of healthy adult volunteers after a single oral dose- to…
The primary objective of this study is to evaluate the long-term maintenance of efficacy of SPD503 in childrenand adolescents (6-17 years) with attention-deficit/hyperactivity disorder (ADHD) who respond to an initial open-label,short-term treatment…
- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IV doses of SAR228810 in…
Primary: To compare the efficacy of aripiprazole with placebo in the suppression of tics in children and adolescents (7-17 years) with a diagnosis of Tourette*s Disorder. The primary efficacy measure is change from Baseline to endpoint (Week 8) on…
- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IVdoses of SAR228810 in AD…
Primary objective of the study: 1. To report on the effectmodification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
The aim of the study is to investigate the effects of atomoxetine on driving performance compared to placebo in 30 adult patients with ADHD. An auditory oddball paradigm will be presented and EEG will be measured during driving to gain insight in…
Objective: 1) To investigate the efficacy of WM training in reducing behavioral symptoms in young children with ADHD.2) To investigate whether WM training improves neurocognitive functioning in young children with ADHD.3) To investigate whether WM…
Primary Objective: The present study aims to test the efficacy of treatment of patients with ADHD, using LENS neurofeedback.
- short-term efficacy of MPH on ADHD symptomatology in adult male SUD patients with ADHD.- short-term influence of MPH on abstinence and drug use- short-term influence of MPH on cocaine craving - safety and adverse effects of MPH in this patient…
The purpose of this trial is to research how the new medication SCH 900062 after single and multiple dosing is absorbed, broken-down and excreted by the body when in the fasting state and after eating a high fat meal. This trial is necessary for the…
The objectives of this study are to establish whether methylphenidate PD effects can be measured using neurocognitive tasks, to describe the drug concentrations of methylphenidate in saliva, to describe the PK/PD relationship using the obtained…
Primary:The primary objective of this study is to evaluate the efficacy of LDX administered as a daily morning dose (30, 50, and 70mg/day) compared to placebo over the course of 7 weeks. This study will enrol children and adolescents (6-17 years of…