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A Two Arm Randomized Clinical Trial comparing the effects of an Elimination Diet and a Healthy Diet in Children with ADHD (TRACE Study). Effects on the Brain * an exploratory investigation

Objective: The present protocol is nested in the TRACE study (CMO 2014-1349, NL50015.091.14 and in the linked TRACE-BIOME study, CMO 2015-1806, NL53630.091.15), and explores whether an ED, compared to healthy diet, affects the fronto-striatal and…

A single-center, non-randomized, open-label, parallel group, two-treatment study investigating the absolute oral bioavailability of balovaptan after single and multiple daily oral doses of balovaptan in healthy volunteers*

The purpose of the study is to investigate how quickly and to what extent balovaptan is absorbed and eliminated from the body when it is administered to healthy volunteers. The pharmacokinetics of balovaptan given by mouth (oral) will be compared…

Effects of daily protein supplementation on brain function in older adults with overweight or obesity

The primary objective is to investigate in overweight or obese older adults the effect of daily protein supplementation for two weeks with either a plant-derived protein or an animal-derived protein on vascular function and insulin-sensitivity in…

Cognitive Functioning And Health Related Quality Of Life In Retinoblastoma Survivors: The Role Of Cancer Treatment And Repeated Anesthesia

The specific aim of the current study is to investigate the impact of oncological treatment and multiple GA in Rb survivors and Rb risk carriers (8-35 years) on cognitive functioning, psychosocial functioning and HRQoL. Furthermore, psychological…