224 results
1. To assess the policy on referral to and use of special outpatient services at 6 years after very preterm birth. 2. To examine whether use of special outpatient services is associated with progress in fysical, cognitive, neuromotor, and behavioral…
The main objective of this study is to evaluate the effectiveness of a newly developed interdisciplinary tailor-made social fitness programme on the participation in meaningful social activities of community-dwelling older people with dementia and…
As only a subgroup of breast cancer patients experience long-term cognitive decline after adjuvant chemotherapy, it is critical to identify risk factors for this decline. Some risk factor like higher age, lower cognitive reserve (either defined as…
The objective of this study is to investigate the acceptance, feasibility and efficacy of cognitive behavioral therapy in reducing ADHD symptoms for adult patients with ADHD and SUD. We will also investigate how substance use and craving are…
The aim of this project is to gain insight in which somatic, cognitive and psychosocialfactors contribute to preservation of functioning, in order to identify older people with potentialrisk of functional decline in an early stage and develop…
The main purpose of the proposed naturalistic pilot study is to compare postsynaptic DA receptor binding (reflecting synaptic DA concentrations) and brain Phe levels in PKU adults with lower blood Phe levels with PKU adults with higher blood Phe…
Primary: To compare the efficacy of aripiprazole with placebo in the suppression of tics in children and adolescents (7-17 years) with a diagnosis of Tourette*s Disorder. The primary efficacy measure is change from Baseline to endpoint (Week 8) on…
Primary: The primary objective of this study is to evaluate the long-term safety of SPD489 administered as adaily morning dose (30, 50, and 70mg) in the treatment of children and adolescents (6-17 years of ageinclusive at the time of consent in this…
- To assess the safety and tolerability of escalating single and multiple IV doses of SAR228810 in AD patients- To evaluate the pharmacokinetic properties of SAR228810 in plasma and CSF after escalating single and multiple IVdoses of SAR228810 in AD…
Primary objective of the study: 1. To report on the effectmodification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
The primary goal of this project is to study whether children with ADHD differ from the normal population on the urinary and plasma levels of the AAA*s (tryptophan, tyrosine and phenylalanine) that are related to the functioning of serotonin and…
The goal of the study is to estimate the prevalence of patients with ADHD in adult outpatient care. About 2300 patients in 8 European countries will participate to this trial. This data will improve the knowledge about the presence and the…
1) To investigate if it is possibility to measure neural activation (CBF) in the DA brain stem nuclei and the functionally associated brain regions with ASL. 2) To investigate the effect of increased DA on activation in the DA system during resting…
This study is performed to asses the effect of MECC system compared to CECC in patients undergoing aortic valve surgery on microemboli in the form of high intensity transient signals (HITS) detected by Transcranial Doppler Ultrasonography (TCD).…
To establish the pharmacokinetic profiles of saliva and plasma concentration of 10 mg MPH-IR and 18 mg MPH-OROS in healthy volunteers; to investigate whether there is a correlation between saliva- and plasma levels of MPH-IR and MPH-OROS, and if…
The overall objectives of CLEAR are to improve our global understanding of the longitudinal impact ofattention-deficit/hyperactivity disorder (ADHD) and contribute to the body of scientific evidence regarding thetreatment and evolution of ADHD over…
To evaluate whether cognitive function of formerly preeclamptics is diminished and correlated with dynamic cerebrovascular control properties using non-invasive measuring techniques (dynamic cerebral autoregulation, neurovascular coupling). Question…
In our recent studies we found indications of the existence of particular cognitive deficits as well as memory impairments following different regiments of cytostatic agents. Together with the indications form our animal studies of a potential…
Examine how unexpected reward and unexpected punishment affect working memory, that is, the ability to maintain information across time, update task-relevant information and ignore task-irrelevant information.Determine the extent to which…
The goals of this study is twofold:At first we want to gain insight in neurocognitive functioning of children and adolescents (12-18 year) with JSLE.Secondly, we want to adapt and validate a Dutch translation of a short "Quality Life…