224 results
The main objective of CRUCIAL-VCI is to determine a surrogate MRI marker for microvascular density in patients with VCI due to cSVD, and to relate this to disease severity expressed as macrostructural brain damage and cognitive function. The…
We aim to assess the association between variability and irregularity in heart rate (as caused by permanent atrial fibrillation), and cognitive function. In addition, variability and irregularity of the peripheral blood pressure will be correlated…
The primary objective of this study is to unravel the effects of dopamine D2 receptor stimulation on gating of working memory, reinforcement learning, and reward-based motivation, and their associated physiological changes (measured with fMRI and…
The primary objective is to understand the overall experience of women with ADHD, to identify barriers to diagnosis and sources of support and explore the links between ADHD and other health conditions. The secondary objective is to identify what…
To investigate the feasibility of a combination therapy (consisting of individualized rTMS and cognitive strategy training) and study measurements in patients with a primary brain tumor during stable disease. The study is considered feasible when 80…
The primary objective is to compare the pharmacological profile of the magistral form of dexamphetamine sulphate to the pharmacological profile of the brand-name form of dexamphetamine (Tentin©) in adult patients diagnosed with attention deficit…
The main objective of this study is to compare the acute effects of methylphenidate on behavioral and cognitive functioning in 6 to 12 year old treatment naïve children compared to the effects after nine months of treatment with methylphenidate in…
To investigate plasticity in the visual cortex in NF1 patients, we will compare the VEPs evoked by checkerboard reversals at baseline and after a modulation block at T1, T2 and T3 of NF1 patients with those of controls.
Primary Objective: To evaluate persisting pulmonary morbidity and echocardiographic signs of pulmonary hypertension in young adults born with CDH that interfere with physical fitness and participation in society.Secondary Objective(s): To evaluate…
To report on the long-term effect modification by age of MPH treatment on brain structure and function, and clinical outcome, as measured by MRI scans, neuropsychological assessment, actigraphy and questionnaires, and to compare these results with…
Primary objective: To test in patients with ESRD whether a longer HD session (8 hours) compared with CHD limits the decline in cerebral blood flow.Secondary objectives: 1) to investigate whether a longer dialysis session is associated with superior…
Primary objective is assessment of the pharmacokinetic profile of MPD in pregnancy. Secondary objectives are the safety and efficacy of any use of MPD during pregnancy.
The aims of the present study are: (1) to assess for the first time in the Netherlands the effectiveness of an adjunctive Alcohol Avoidance Training (AAT) during inpatient alcohol detoxification to improve treatment outcomes. (2) To investigate for…
Primary Objective: - To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors.Secondary Objective(s): - To identify specific patterns of brain…
Goal of the study is to find out if cognitive remediation focused on executive functioning for patients with bipolar disorder improves (1) functioning on personal goals in everyday life? And (2) improves general wellbeing?Hypotheses:Cognitive…
To validate SAI as a measure for cholinergic innervation by relating SAI directly to [18F]FEOBV PET imaging. The secundary aims are as follows: - To assess the correlation between SAI and cognitive functioning, motor symptoms, RBD, walking speed,…
Primary objective of the study: 1. To report on the long-term effect modification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
To determine the difference in change over time of cognitive function and brain magnetic resonance imaging (MRI) measurements between breast cancer survivors and cancer-free individuals.
The objective of this study is to elucidate unique and shared impairments across a broad range of social cognition tasks (at the behavioral, neuropsychological, and neurophysiological level by means of EEG recordings) related to subdimensions of…
In this study, we aim to validate the TICS and MoCA questionnaires against NPT, hoping to find a patient friendly and easy to use screening aid for preoperative evaluation clinics. Thus, aiding shared decision making regarding the appropriate…