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Neurotoxic adverse effects of morphine and oxycodone in continuous subcutaneous infusion for treatment of pain in terminal patients with diminished renal function: a Randomized Controlled Trial.

The primary objective of this study is to compare the prevalence of delirium between oxycodone and morphine, administered by CSCI, for the treatment of pain in dying patients with a diminished renal function.The secondary objective is to compare the…

Nicotine Replacement Therapy in the Intensive Care Unit: a randomized, controlled pilot study.

To determine the safety and efficacy of transdermal nicotine replacement therapy in mechanically ventilated and active smoking patients admitted to the intensive care unit.

Dexmedetomidine vs. clonidine in delirious intensive care patients: a randomised open-label trial

Primary objective:the effects of sedation with clonidine or dexmedetomidine on the duration of haloperidol-resistent delirium in intensive care patientsSecondary objectives:the effect of treatment with clonidine or dexmedetomidine on1. total of…

Spinal morphine in patients with hip fractures to reduce delirium

The main objective is to decrease the incidence of delirium in patients receiving surgical treatment of a proximal femur fracture with spinal anesthesia.

Prevention of neuropsychiatric adverse effects caused by dexamethasone: insights from a placebo-controlled trial with hydrocortisone.

Investigate whether a low-dose of hydrocortisone (cortisol) reduces neuropsychiatric symptoms in glioma, meningioma and brain metastasis patients who are perioperatively treated with a high dose of the synthetic glucocorticoid dexamethasone,…