55 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…
The objectives of this study are as follows:1) To determine the sensitivity and reproducibility of novel assays developed at the Janssen Prevention Center to detect anti-tau immune responses in the blood of individuals.2) To determine the…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Objective of the project is to the American EDDI translate and adapt to the Dutch situation. Then, in a pilot study there will be examined whether the intervention is applicable to people with dementia and their caregiver, and if so, under what…
The present PhD thesis focuses on the investigation of ADAS and the older driver. Even though, recent research investigated the effects of ADAS on driving performance, little is known about the long-term effects of the systems on performance.…
The primary objective is to examine the relationships between the cognitive tests results of the neuropsychological assessment and dual-task cost in elderly with cognitive impairment. The second objective is to examine differences in gait…
Our aim is to determine the effect of APO* on activity and volume of the hippocampus, a core structure of Alzheimer pathology, at a young age. Specifically, we aim 1) to determine the effects of APOE e4 on hippocampal activation in the young general…
In the current study, the effect of oral health care and normal diet on quality of life of elderly persons suffering from dementia.The results from the baseline assessment will be used as cross-sectional data to establish correlations between the…
Investigate the degree of association between the level of AGE*s and the development and progression of paratonia in Alzheimer*s Disease (AD).Research questions are:(1) Are elevated levels of AGE*s, at baseline and during 12 months follow-up,…
In the present project we aim to develop a first working platform for interactive, home-based blood pressure screening and monitoring by using internet and smartphone technology in middle-aged offspring of patients with dementia.
RationaleSince gamma band activity is thought to be an important mechanism in perceptual binding and cognitive function, interest in changes in gamma band activity in neuropsychiatric disorders has grown rapidly. Changes in gamma band oscillations…
The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…
Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
investigate who is at risk and to discover possible contributing factors of the development of paratonia in different dementing illnesses
Objective: to provide an answer to the following question: in patients with AD, does treatment with a ChEI improve cerebral autoregulation?
To study the short term effects of a pharmacological dose of fish oil on cognitive performance and on cerebral blood flow. Furthermore, we want to investigate whether carriers of the APOE*4 allele respond differently to fish oil treatment compared…
Primary Objective: Our primary objective is to test the feasibility of the online In-MINDD intervention through a primary care-based feasibility RCT. We hypothesize, that providing persons with information on their health profile and access to…
This project aims to determine the effects of an extensive exercise program in MCI patients with respect to the progression of the disease