14 results
To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ALKS 7119 following oral administration of single ascending doses of ALKS 7119 in healthy male adults
Primary Objective:The primary objective of this study is to determine whether treatment with JNJ-54861911 slows cognitive decline compared with placebo treatment, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive…
To identify novel diagnostic and prognostic (bio)markers of Dementia with Lewy Bodies.
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
The objective of the current study proposal is therefore to investigate *the origin of cerebral small vessel disease*
Main objectives are to investigate the cognitive effects of alternating endurance-strength training in APOEe4 carriers and non-carriers in early stage dementia and to identify a dose-response relationship of the cognitive effects of exercise.…
Our aim is to investigate the cognitive effects of an interactive cycling training in early stage dementia patients (in comparison to an aerobic cycling training and a control group).In addition we will investigate whether the effects of training…
Determine the reliability, validity and the sensitivity to change of the MYOTON Handheld Digital Palpation Device for measuring the severity of paratonia in patients with dementia and paratonia .Research questions are:(1) What is the validity of the…
Main objectives Part 1• To evaluate the safety and tolerability of a single oral dose of HTL0018318, administered at one of at least three ascending dose levels (maximum of 8 ascending dose levels), in healthy younger adult male subjects.• To…
Primary objective:To explore the natural time course of specific [18F]AV-1451 binding in patients with subjective cognitive decline after two and four year follow upa. To compare rate of change in [18F]AV-1451 binding according to baseline amyloid…
We aim to assess whether aerobic exercise leads to increased cerebral perfusion in patients with vascular cognitive impairment.
Part 1: Main objective: Investigate the relation between level of physical (in)activity and cognition in healthy elderly and to examine the possible moderating effects of (Apolipoprotein E e4) APOEe4 status and IGF-1 and BDNF levels and blood…
To examine whether providing feedback to patients immediately after scoring in a non-valid range on a SVT would have an impact on subsequent symptom validity and neuropsychological test performance. Furthermore, we examine treatment-outcome as a…
The overall aim of this study is to develop a short and clinically relevant composite measure, which is able to detect changes in cognition and everyday functioning across the disease spectrum of Alzheimer*s Disease (AD). We will achieve this aim by…