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Synaptic density and tau pathology in Alzheimer's disease

This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…

Clinical Implementation of Amyloid Neurodegeneration and Tau testing in Primary Care.

The objective of this study is, to detect potential uses of plasma biomarkers in primary care, by (a) To investigate if plasma biomarkers are associated with working diagnosis in primary care.(b) To ascertain if diagnosis and patient management…

Measuring blood-brain barrier integrity non-invasively with MRI

This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.

Primary care diagnostics or diagnostics in a memory clinic in older persons with memory complaints - A long-term cost-effectiveness trial with non-inferiority design

What is the comparative efficacy and safety between dementia diagnostics in primary care and dementia diagnostics in a memory clinic for older persons with memory complaints?

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE AND MULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS

This study has been transitioned to CTIS with ID 2024-517955-10-00 check the CTIS register for the current data. In this study we will investigate how safe the new compound THN391 is and how well it is tolerated when it is used by healthy subjects.…