30 results
The aims of this research are to estimate the efficacy of a relatively brief group CBT for bipolar disorders, by following the level of mood symptoms over time, and by assessing whether changes in dysfunctional attitudes and sense of mastery over…
Primary objective: evaluation of feasibility of a pilot intervention by measuring adherence to the training program and evaluation of the different aspects by the participants Secondary objective: measuring possible beneficial effects on all domains…
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
Little research is being done on the effects of psychological treatment in patients with a bipolar disorder (BD) and comorbide borderline personality disorder (BPD) features. There are no recommendations included in the guideline for BD (Nolen et al…
As there are limited data on how to improve outcomes for those patients who do not benefit sufficiently from the availabletreatments, this study aims to compare MBCT to TAU as an adjunctive treatment to reduce depressive symptoms in patientswith…
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
The objective of this study is to include 200 cases, 200 unaffected first and second degree family members and 200 unrelated healthy controls to participate in the assessment of variability in activity and light exposure, as these domains are…
We expect Collaborative Care to have a positive effect on functioning, amount and severity of symptoms, quality of life, costs, mastery, attitude to pharmacotherapy, and satisfaction with care. If effect of this intervention can be demonstrated we…
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
Purpose of the study is to understand women with bipolar disorder in their decision-making process concerning family planning or prior to any pregnancy.
The main purpose of the study is to investigate whether the transdermal patch system HP-3070 shows blood concentrations of asenapine that make this route of administration suitable for clinical use. The transdermal route of administration is likely…
Primary objective: To investigate whether sleep disturbances during pregnancy and/or in the perinatal period will predict postpartum psychopathology in women with an established diagnosis of bipolar disorder and/or a history of postpartum psychosis.…
To evaluate two biomarker tests (characterized by an activated inflammatory response system (IRS) as reflected by an aberrant monocyte gene expression signature and/or a disturbed metabolism of tryptophan) by comparing patients with BD with healthy…
Study A: Show BP patients similar progression in brain volume change compared to schizophrenia patients. If so, can the progressive change in BP patients also be explained by genetic factors?Study B: Show BP patients and their non-bipolar cotwins…
1. Define risk profiles based on retrospective data in a cohort of bipolar patients. These profiles will be based on the effects of various combinations of MR and GR genotypes involved in stress regulation on symptoms, course of the illness and…
The objective of the study is to investigate the long-termeffects of lithium on the development of children who are exposed to lithium during pregnancy.
The objective of the current study is to investigate the feasibility of a within subject longitudinal design to investigate the relationship between cognition, mood, clinical factors and other psychosocial variables that may be of influence in…
We want to identify perception biases in bipolar patients with both depressive and hypomanic mood symptoms.
The primary aim of this study is to investigate if prophylactic pharmacotherapy peripartum is associated with a lower chance of relapse peripartum. In more detail, we will investigate if there is a difference in relapse between patients that used…
The aim of the study is to investigate the effectiveness of schema therapy in older adults with BPD.