26 results
The aims of this research are to estimate the efficacy of a relatively brief group CBT for bipolar disorders, by following the level of mood symptoms over time, and by assessing whether changes in dysfunctional attitudes and sense of mastery over…
Primary objective: evaluation of feasibility of a pilot intervention by measuring adherence to the training program and evaluation of the different aspects by the participants Secondary objective: measuring possible beneficial effects on all domains…
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
As there are limited data on how to improve outcomes for those patients who do not benefit sufficiently from the availabletreatments, this study aims to compare MBCT to TAU as an adjunctive treatment to reduce depressive symptoms in patientswith…
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
The objective of this study is to include 200 cases, 200 unaffected first and second degree family members and 200 unrelated healthy controls to participate in the assessment of variability in activity and light exposure, as these domains are…
We expect Collaborative Care to have a positive effect on functioning, amount and severity of symptoms, quality of life, costs, mastery, attitude to pharmacotherapy, and satisfaction with care. If effect of this intervention can be demonstrated we…
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
The main purpose of the study is to investigate whether the transdermal patch system HP-3070 shows blood concentrations of asenapine that make this route of administration suitable for clinical use. The transdermal route of administration is likely…
Study A: Show BP patients similar progression in brain volume change compared to schizophrenia patients. If so, can the progressive change in BP patients also be explained by genetic factors?Study B: Show BP patients and their non-bipolar cotwins…
1. Define risk profiles based on retrospective data in a cohort of bipolar patients. These profiles will be based on the effects of various combinations of MR and GR genotypes involved in stress regulation on symptoms, course of the illness and…
To compare the effect of amiloride on lithium-induced Nephrogenic Diabetes Insipidus with the effect of hydrochlorothiazide, measured as urine volume and maximal urine osmolality.
The objective of the study is to investigate the long-termeffects of lithium on the development of children who are exposed to lithium during pregnancy.
The objective of the current study is to investigate the feasibility of a within subject longitudinal design to investigate the relationship between cognition, mood, clinical factors and other psychosocial variables that may be of influence in…
The primary objective of the study is to investigate whether CRT reduces subjective cognitive symptoms. It is hypothesized that there is a significant improvement in subjective cognitive symptoms as measured by the Cognitive Failure Questionnaire (…
Objective: We want to determine the effectiveness of rTMS in patients with bipolar depression who did not respond to two or more adequately dosed medication trials, using an adequately powered pragmatic RCT. We hypothesize that active rTMS, compared…
Primary Objective: To confirm that the lithium headcoil is capable of measuring lithium signals related to clinical doses in the brains of BD patients (MDR, art 82), and then to establish the correlation of neuroimaging data of lithium…
The primary objective of this trial is to investigate the effects of probiotics, as compared to placebo, when given in addition to antipsychotic/mood stabilizing medication to a selected patient sample. Our aim will be to lower symptom severity as…
Primary Objective: To identify immuno-endocrine and neuro-imaging parameters differentiating between different mood states (manic, depressive, and euthymic). Secondary Objectives: 1. To identify the influence of these parameters on the onset and…
The primary objective is the extent and kind of cognitive deficits in patients suffering from bipolar disorders compared to healthy controls and patients with a lifetime diagnosis of unipolar depressive disorder. Secondary objectives specify the…